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Jan 16, 2014

The citrullination of proteins is a post-translational modification where peptidyl arginine residues are converted to peptidyl citrulline by a family of enzymes called peptidyl arginine deiminases (PADs). Citrullination can be found in multiple tissue types and has been shown to occur in both...

Oct 7, 2013

Rat insulin is a pancreatic hormone whose molecular weight is about 6000 Da. It is a protein composed of two polypeptide chains, a shorter A-chain of twenty-one residues and a longer B-chain of thirty. The two chains are connected by two disulphide (-S-S-) linkages, while a third such linkage...

Aug 30, 2013

Tumor necrosis factor alpha (TNF-alpha) is associated with numerous diseases due to its role in inflammation and autoimmunity that include rheumatoid arthritis (RA), inflammatory bowel disease (IBS), psoriasis, and multiple sclerosis (MS).

TNF-alpha is a potent cytokine with a myriad...

May 7, 2013

Stress can be physical, emotional or psychological. Depending on the pressures you are facing it can have varying effects on your body. When stressful situations occur your body releases stress hormones that give you the ability to fight back to intensify your concentration and your reaction...

Jan 22, 2013

IL-33 is mainly expressed by fibroblasts, epithelial cells and endothelial cells. It is the ligand for orphan receptor, ST2. IL-33-ST2 plays a dual role, in some cases promotes Th2 cells and in other cases...

Nov 28, 2012

Arthritis PathologyRheumatoid arthritis (RA) is a chronic systemic autoimmune disease that affects approximately 1% of the...

Nov 2, 2012

Highly purified collagen type II is important for the induction of arthritis. The rate of incidence is a sore topic among many that are running the collagen induced arthritis model given disease incidence as low as 50% is not uncommon.  The purity of the collagen, adjuvant quality, emulsion...

Jul 19, 2011

IL-33/ST2 signaling pathway, ST2 antibodiesST2 (also known as T1) is a...

Apr 25, 2011

A recent publication using rabbit anti-mouse polyclonal antibody for immunoblotting collagen extracted from cervical tissue of pregnant and non-pregnant mice. The aim of the study is to gain a...