Citation: identifying changes in cervical ECM early in pregnancy. Rabbit anti-mouse polyclonal antibody

A recent publication using rabbit anti-mouse polyclonal antibody for immunoblotting collagen extracted from cervical tissue of pregnant and non-pregnant mice. The aim of the study is to gain a greater understanding of the parturition process for prevention of pre-term births. The results identify changes in the cervical ECM early in pregnancy that contribute cumulatively to the progressive decline in tensile strength during the cervical softening phase. The study enhances the understanding of the progressive physiological changes in normal cervical softening and identifies specific genes/proteins in which mutations or misregulation may account for clinical complications that contribute to the risk of preterm births.

Cervical Softening During Pregnancy: Regulated Changes in Collagen Cross-Linking and Composition of Matricellular Proteins in the Mouse
Meredith L. Akins, Katherine Luby-Phelps, Ruud A. Bank, and Mala Mahendroo
Biol Reprod, May 2011; 84: 1053 - 1062.

Product: Rabbit anti-mouse collagen I polyclonal antibody, Catalog 203002 (previously MD20151).