IL-18R Antibody
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Interleukin-18 Receptor (IL-18R) polyclonal antibody (rabbit anti-human) specific for IL-18R on the surface of Th1/Tc1 cells.
Overview
Interleukin-18 receptor (IL-18R) is found to be expressed on memory T1 and T2 PBMC (peripheral blood memory leukocytes). The receptor is comprised of alpha and beta-chains that are encoded by the genes IL18R1 and IL18RAP. The IL-18R receptor mediates functions of the IL-18 cytokine including pro-inflammatory properties. The antibody can be used to understand the physiological and pathological functions of IL-18 responsiveness and for the study of signal transduction mechanisms. Furthermore, the antibody can be used as a marker to monitor lymphocyte subset changes in human disease.
Symbols/Alternate Terms:
- IL18R1
- IL18RAP
Data/Specifications
Form: 0.5 mL vial, supplied with 0.5 mL of pre-immune matched normal rabbit serum as control.
Specificity: Human Interleukin 18 Receptor, a cell surface marker present specifically on Th1/Tc1 cells.
Immunogen: A keyhole limpet haemocyanin-conjugated peptide to hlL-18R extracellular domain.
Literature/Support
IL-18R Antibody Insert (PDF, 228 KB)
| References/Citations: | The IL-18R Antibody was used for: |
| Human IL-18 Receptor and ST2L are stable and selective markers for respective type 1 and type 2 circulating lymphocytes. Chan WL, et al. J Immunol. 2001 Aug 1; 167(3):1238-44. | Flow cytometry analysis of human cells. |
How To Use
Application
- Use as a specific Th1/Tc1 marker.
- Suggested usage at 1/25 and detection with biotinylated goat anti-rabbit IgG followed by fluorochrome conjugated streptavidin for flow cytometry (FACS).
- Also suitable for cell sorting and immunohistochemistry using fluorochrome detection.