COMP ELISA
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The Animal COMP ELISA kit is used to measure Cartlilage Oligomeric Matrix Protein (COMP) levels in Rat, Mouse, Sheep and Bovine serum.
Overview
COMP is a protein which is released in the blood when cartilage is destroyed and can be used prognostically for cartilage destruction in inflammatory joint diseases such as rheumatoid arthritis (RA) and osteoarthritis (OA). A quantitative relation between COMP concentration in serum and the degree of cartilage destruction destruction has been shown.
Data/Specifications
Species: Rat, mouse, pig, sheep, goat, bovine
Sample Type: serum
Sample Preparation: Dilute 1:10
Sample Size: 50 uL
Standard Curve Range: up to 0.9 U/L
Sensitivity: <0.2 U/L
Assay Length: 3 hrs
Literature/Support
Animal COMP ELISA Insert (PDF)
References/Citations: | How the COMP ELISA Kit was used: |
| Reversible changes in serum immunoglobulin galactosylation during the immune response and treatment of inflammatory autoimmune arthritis. Van Beneden K, et al. Annals of the rheumatic disease. 2009; 68(8):1360-5. | Measure the concentration of COMP in serum from DBA/1 mice (8 to 12 weeks old). |
| Effects of simple and complex motion patterns on gene expression of chondrocytes seeded in 3D scaffolds. Grad S, et al. Tissue Engineering. 2006; 12(1): 3171-3179. | Measure the concentration of COMP in the media of chondrocyte cultures. Chondrocytes were isolated from metacarpal joint cartilage of young (3-4 months old) calves. |
| Kv1.3 channels are a therapeutic target for T cell-mediated autoimmune diseases Christine Beeton et al., PNAS, Nov 2006; 103: 17414 - 17419. Supporing Literature (View here) | Measure the concentration of cartilage oligomeric matrix protein in the sera of rats (referenced in article supporting information). |
| Measurement of arthritic and bone serum metabolites in arthritic, non-arthritic, and geriatric dogs fed wellness foods. Yamka R, et al. Intern J Appl Res Vet Med 2006; 4(3):255-64. | Measure the concentration of cartilage oligomeric matrix protein in canine serum. |