Proteoglycan, Septum Cartilage Extract
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Human Septum Cartilage Extract - Proteoglycans are purified from human septum cartilage.
Overview
Proteoglycans are a major component of the animal extracellular matrix where they form large complexes with other proteoglycans, hyaluronan, and collagen. They are involved in regulating the movement of molecules through the matrix and can affect the activity and stability of proteins and signalling molecules within the matrix. The inability to break down proteoglycans is characteristic of a group of genetic disorders and leads to a variety of disease symptoms depending upon the type of proteoglycan that is not degraded.
Data/Specifications
Molecular Form:
Human Septum Cartilage Extract - Proteoglycans is purified from human septum cartilage using Guanidin-HCl extraction, pepsin digestion, ethanol precipitation, potassium-acetate extraction and chromatography. The mixture contains large proteoglycans consisting of core proteins with attached glycosaminoglycans. Major components of the mixture are aggrecan and versican, which are hyaluronic acid-binding proteoglycans. Both contain hyaluronic acid binding regions, Iglike domains, EGF-like domains and lectin-like domains. As macromolecular polyanions, they expand and hydrate the ECM in cartilage, intervertebral discs, dermis, blood vessel walls and brain tissue. Aggrecan and versican are degraded by proteases of the ADAMTS family. Aggrecan is cleaved by ADAMTS -1, -4, -5, -8, -9 and -15. Versican is hydrolyzed by ADAMTS -1, -4 and -9.
Concentration:
1 mg/mL as determined with bicinchoninic acid reagent
Form: Lyophilized
Literature/Support
Human Septum Cartilage Extract Proteoglycan Insert (PDF, 226 KB)
How To Use
Human Septum Cartilage Extract – Proteoglycans can be used as a source for aggrecan, versican and other human proteoglycans.