Literature

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Articles

Matrix Metalloproteinases

Matrix metalloproteinases (MMPs) comprise a family of secreted and membrane-bound endopeptides that hydrolyze extracellular matrix proteins (ECM). Based on their preferred substrates and structural features, MMPs can be divided into collagenases, gelatinases, stromelysins, matrilysins and membrane-type matrix metalloproteinases (MT-MMP). MMp mediated ECM degradation affects processes such as connective tissue remodeling, cell migration and cell micro-environment regulation. MMPs further affect cellular behavior by modulatin the activities of cytokines, growth factors cell surface receptors and other MMPs. In addtion to their normal function in developmental and repair processes, inappropriate MMP activity also participates in diseases processes including arthritis and cancer.

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An ELISA to Measure Proteolytic Degradation of Aggrecan: Hallmark in the pathology of Arthritis.

Aggrecan is a large aggregating proteoglycan of articular cartilage (1), making up 10% of the dry weight. It is responsible for hydrating cartilage giving it compressibility and resilience during joint loading, thereby playing a major role in the normal function of cartilage. Depletion of glycosaminoglycan bearing aggrecan fragments from articular cartilage is one of the earliest events in cartilage destruction.

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