Human ST2L biotinylated monoclonal antibody (Clone B4E6) for the identification and purification of human type 2 lymphocyte (Th2) subsets
Overview
Overview:
T1/ST2 (also known as IL-1 R4 or IL-33Ra) is a transmembrane glycoprotein expressed on mast cells and Th2 cells. It is a selective marker for both murine and human Th2 lymphocytes and plays a role in regulating inflammatory responses. IL-33 is a recently identified member of the IL-1 family of cytokines and is involved in Th2 mediated immune responses. IL-33 mediates its biological effects via T1/ST2 binding. The roles of IL-33 and T1/ST2 (IL-33Ra) have been investigated in many immune responses such as allergy, asthma, rheumatoid arthritis and osteoarthritis.
Data/Specifications
Data/Specifications:
Clone: B4E6
IgG Subclass: IgG1
Form: The biotinylated antibody is supplied in PBS and purified over protein G-sepharose from concentrated tissue culture supernatant. The antibody is supplied with 0.1% sodium azide as preservative.
Specificity: This clone recognizes hST2L specifically on the cell surface of human type 2 (Th2, Tc2, NK2 and NKT2) but not type 1 lymphocytes.
How To Use
How To Use:
Applications
- Flow cytometry
- FACS
- cell sorting
- immunohistochemistry with hybridoma culture supernatant