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Increasing the rate of incidence in the Collagen-induced Arthritis model

Highly purified collagen type II is important for the induction of arthritis. The rate of incidence is a sore topic among many that are running the collagen induced arthritis model given disease incidence as low as 50% is not uncommon.  The purity of the collagen, adjuvant quality, emulsion preparation, animal strain, animal diet, environment and stress are all factors that can affect the rate of incidence. Here are some tips for increasing the rate of incidence in the collagen-induced arthritis model.