Uromodulin (THP) Levels in Kidney Disease

Uromodulin (THP) Levels in Kidney Disease

Aug 31 , 2022

MD Bioproducts

Uromodulin Glycoprotein (UMOD,Tamm-Horsfall Protein, THP) is the most abundant protein found in the urine of mammals. THP is 616 amino acids in length with a molecular weight of 80 kDa and is synthesized in the thick ascending loop of Henle. While the specific function of THP is unknown, it appears to have a role in the regulation of salt and water excretion by the kidney. Soluble THP has been found to help protect against urinary tract infections of E. coli and P. mirabilis by inhibiting the binding of the bacteria to the epithelial cells of the urinary tract. In addition, it has been suggested that THP may help prevent renal stone formation. Defects in THP are associated with human diseases such as familial juvenile hyperuricemic nephropathy (FJHN) and medullary cystic kidney disease (MCKD2).

A rapid, sensitive, and easy-to-use assay, MD Bioproducts’ highly cited MonELISA® Uromodulin Glycoprotein Kit provides precise and reproducible results.

MonELISA® Uromodulin Glycoprotein Kit, Catalog No. M036020
The MD Bioproducts MonELISA Uromodulin Glycoprotein ELISA kit
(96 wells) is used for the quantitative determination of Uromodulin Glycoprotein (THP) in human, canine and mouse urine samples in less than 3 hours.

MonELISA® Ancillary Reagent Kit, Catalog Number M036080
The MonELISA Ancillary Kit is provided separately and contains enough reagents to be used with up to 5 kits of Uromodulin Glycoprotein MonELISA for a truly flexible and cost-effective advantage. 

To learn more about MonELISA®, a mix and match system applying flexible protocols for the convenient use with other MonELISA immunoassays, click here.

Selection of Citations:

Steenbeke, M., De Buyzere, M. L., Speeckaert, M. M., & Delanghe, J. R. (2021). On the protein content of kidney stones: an explorative study. Acta Clinica Belgica, 1-8.

Steubl, D., Buzkova, P., Ix, J. H., Devarajan, P., Bennett, M. R., Chaves, P. H., ... & Garimella, P. S. (2020). Association of serum and urinary uromodulin and their correlates in older adults—The Cardiovascular Health Study. Nephrology, 25(7), 522-526. 

Amatruda, J. G., Katz, R., Peralta, C. A., Estrella, M. M., Sarathy, H., Fried, L. F., & Health ABC Study. (2020). Association of Non‐Steroidal Anti‐Inflammatory Drugs with Kidney Health in Ambulatory Older Adults. Journal of the American Geriatrics Society. 

Garimella, P. S., Jaber, B. L., Tighiouart, H., Liangos, O., Bennett, M. R., Devarajan, P., & Sarnak, M. J. (2017). Association of preoperative urinary uromodulin with AKI after cardiac surgery. Clinical Journal of the American Society of Nephrology, 12(1), 10-18. 

Tomlinson, J. A., Caplin, B., Boruc, O., Bruce-Cobbold, C., Cutillas, P., Dormann, D., ... & Leiper, J. (2015). Reduced renal methylarginine metabolism protects against progressive kidney damage. Journal of the American Society of Nephrology, 26(12), 3045-3059.