Collagen Type II, Bovine, Immunization Grade, Soluble, 2 mg/mL

Immunization Grade Collagen type II (CII) protein, purified from fetal bovine articular cartilage, for the induction of arthritis in the Collagen-Induced Arthritis (CIA) model. Soluble 5 mL (2 mg/mL) Type II...



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For research use only. Not for use in diagnostic procedures.

Immunization Grade Collagen type II (CII) protein, purified from fetal bovine articular cartilage, for the induction of arthritis in the Collagen-Induced Arthritis (CIA) model. Soluble 5 mL (2 mg/mL)

Type II collagen (CII) is a fibrillar collagen that is primarily located in cartilage tissue. The major molecular form of collagen in cartilage is type II collagen. Type II collagen is also located in the vitreous humor of the eye, the inner ear, the nose, and the intervertebral discs of the spine. The function of type II collagen is to provide tensile strength and give cartilage the ability to resist shearing forces. Mutations of the COL2A1 gene affect the synthesis of type II collagen and cause chondrodysplasias. This is characterized by abnormal cartilage that leads to bone and joint deformities. The degradation of collagen type II is an early indicator of osteoarthritis.

Type II Collagen and Adjuvent Susceptibility to CIA is linked to MHC class II molecules and is dependent upon the species of type II collagen used for immunization. Various species of highly purified Type II Collagen are supplied lyophilized and in solution for use in the induction of arthritis in vivo.

Symbols/Related Terms:

  • COL2A1
  • pro-alpha 1(II) chain
  • Achondrogenesis
  • Hypochondrogenesis
  • Spondyloepimetaphyseal dysplasia
  • Osteoarthritis (OA)
  • Collagen Induced Arthritis (CIA)


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A Virus-Like Particle-Based Anti-Nerve Growth Factor Vaccine Reduces Inflammatory Hyperalgesia: Potential Long-Term Therapy for Chronic Pain
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Product Insert (PDF) - Informational use only. Please refer to insert included with product.


  • Concentration: 2 mg/mL
  • Purity: >99% as determined by SDS-PAGE and visualized by Coomassie blue staining
  • Purification: Differential salt precipitation
  • Source: Fetal bovine articular cartilage
  • Form: soluble
  • Application: Induction of Collagen-induced arthritis (CIA) in experimental animals

Technical tips

  • To ensure collagen retains its native structure, always use pre-chilled pipette tips, glassware, and diluent.
  • Keep collagen on ice during use.
  • When preparing emulsion for Collagen-induced arthritis induction, ensure that emulsion is thick to give best rate of incidence.
  • Use high quality CFA (Complete Freund’s Adjuvant) at a concentration up to 4mg/mL