Cartilage Link Protein, Antibody

Monoclonal Antibody to Cartilage Link Protein, clone 8A4
Catalog Number: 
1042013
Qty/Size: 
100 ug

monoclonal antibody to cartilage link protein, clone 8A4 from MD Bioproducts

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Cartilage-link protein (HAPLN1) monoclonal antibody (clone 8A4).

Overview

Overview: 

Cartilage-link protein (LP) is a glycoprotein present in cartilage that stabilizes the interaction of aggrecan (versican) with hyaluronic acid (HA) in large proteoglycan aggregates.

 

Related Terms/Symbols:

  • Anti-HAPLN1 antibody
  • CRTL1
  • Hyaluronan and proteoglycan link protein 1
  • LP
  • Proteoglycan link protein
  • Cartilage-linking protein 1
  • HAPLN1 gene
  • P10915

 

 

 

Data/Specifications

Data/Specifications: 

Immunogen: Link Protein from Bovine nasal cartilage

 

Clone: 8A4

 

Host: Mouse

 

Isotype: IgG

 

Specificity: This antibody recognizes the structurally related amino acid sequence epitopes … PISRP… and ….PITKP that occur in the two proteoglycan tandem repeat motifs of cartilage LP. This antibody can be used to detect intact LP 1,2 & 3 as well as a large number of smaller fragments that are generated through proteolytic cleavage during LP catabolism. It recognizes LP in all animal species from chicken to humans.

 

Purity: Affinity purified

 

Form: Clear liquid

 

Concentration: 0.1 mg/mL

 

Storage: -20° C

Literature/Support

Literature/Support: 

How To Use

How To Use: 

Applications

Western Blot

IHC

RIA

 

Technical Notes

No enzyme pretreatment required, however chondroitinase and hyaluronidase will increase antibody sensitivity by exposing epitopes. For WB chondroitinase and hyaluronidase treatment is recommended.