Cartilage Link Protein, Antibody
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Cartilage-link protein (HAPLN1) monoclonal antibody (clone 8A4).
Overview
Cartilage-link protein (LP) is a glycoprotein present in cartilage that stabilizes the interaction of aggrecan (versican) with hyaluronic acid (HA) in large proteoglycan aggregates.
Related Terms/Symbols:
- Anti-HAPLN1 antibody
- CRTL1
- Hyaluronan and proteoglycan link protein 1
- LP
- Proteoglycan link protein
- Cartilage-linking protein 1
- HAPLN1 gene
- P10915
Data/Specifications
Immunogen: Link Protein from Bovine nasal cartilage
Clone: 8A4
Host: Mouse
Isotype: IgG
Specificity: This antibody recognizes the structurally related amino acid sequence epitopes … PISRP… and ….PITKP that occur in the two proteoglycan tandem repeat motifs of cartilage LP. This antibody can be used to detect intact LP 1,2 & 3 as well as a large number of smaller fragments that are generated through proteolytic cleavage during LP catabolism. It recognizes LP in all animal species from chicken to humans.
Purity: Affinity purified
Form: Clear liquid
Concentration: 0.1 mg/mL
Storage: -20° C
Literature/Support
Antibody to Cartilage Link Protein Insert (PDF, 328 KB)
Joint Disease and Aggrecan (blog post)
How To Use
Applications
Western Blot
IHC
RIA
Technical Notes
No enzyme pretreatment required, however chondroitinase and hyaluronidase will increase antibody sensitivity by exposing epitopes. For WB chondroitinase and hyaluronidase treatment is recommended.