Citrullinated Collagen Type II Antibody (Clone ACC-1)
Please register to view price.
North America: 1-888-USMDBIO
International: +41-44 986 2628
Or you can order by using our online form
Have questions or need bulk? No problem, just ask.
Citrullinated collagen type II (Citrullinated CII) monoclonal antibody (mouse) for the detection of Citrullinated type II collagen in immuno assay applications.
Overview
The citrullination of proteins is a post-translational modification where peptidyl arginine residues are converted to peptidyl citrulline by a family of enzymes called peptidyl arginine deiminases (PADs). Citrullination can be found in multiple tissue types and has been shown to occur in both human and mouse inflamed joints (1,2, 3). Proteins are susceptible to citrullination during inflammatory processes and an autoantibody response to citrullinated proteins is a hallmark of Rheumatoid Arthritis (RA). Antibodies against citrullinated proteins (ACPAs) can be found in 50-70% of all RA patients and have a high diagnostic value as a biomarker for detecting RA early (4,5). Current research is focused on understanding the detailed mechanisms causing direct inflammation of the joints and the self-perpetuating behavior of RA, via the recognition of post-translation modifications such as citrullination by T and B cells.
Data/Specifications
Immunogen: Citrullinated collagen type II peptide
Clone: ACC-1
Host: Mouse
Isotype: IgG2a
Specificity: The antibody binds to the triple helical citrullinated C1 epitope of CII. The C1 epitope containes 2 arginines which can be postranslationally converted to citrulline. This antibody will recognize the 2nd citrulline at position 365. Cross-reactivity is exhibited with denatured CII as well as denatured C1 epitope.
Purity: Protein A purified
Form: Liquid, 1 mL/vial
Concentration: 0.1 mg/mL
Storage: -20° C
Literature/Support
Citrullinated CII Antibody, Clone ACC-1 Insert (PDF, 228 KB)
How To Use
Applications
- ELISA
- IHC