IL-18R Antibody
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Interleukin-18 Receptor (IL-18R) polyclonal antibody (rabbit anti-human) specific for IL-18R on the surface of Th1/Tc1 cells.
Overview
Interleukin-18 receptor (IL-18R) is found to be expressed on memory T1 and T2 PBMC (peripheral blood memory leukocytes). The receptor is comprised of alpha and beta-chains that are encoded by the genes IL18R1 and IL18RAP. The IL-18R receptor mediates functions of the IL-18 cytokine including pro-inflammatory properties. The antibody can be used to understand the physiological and pathological functions of IL-18 responsiveness and for the study of signal transduction mechanisms. Furthermore, the antibody can be used as a marker to monitor lymphocyte subset changes in human disease.
Symbols/Alternate Terms:
- IL18R1
- IL18RAP
Data/Specifications
Form: 0.5 mL vial, supplied with 0.5 mL of pre-immune matched normal rabbit serum as control.
Specificity: Human Interleukin 18 Receptor, a cell surface marker present specifically on Th1/Tc1 cells.
Immunogen: A keyhole limpet haemocyanin-conjugated peptide to hlL-18R extracellular domain.
Literature/Support
IL-18R Antibody Insert (PDF, 228 KB)
| References/Citations: | The IL-18R Antibody was used for: |
Predominance of Th2 response in human abdominal aortic aneurysm: Mistaken identity for IL-4-producing NK and NKT cells? Chan WL, et al. Cellular Immun (2005) 233:109-114
| Application of ST2L and IL18R markers in absdominal aortic aneurysms |
| Changes in systemic type 1 and type 2 immunity in normal pregnancy and pre-eclampsia may be mediated by natural killer cells Borzychowski, A.M. et al., Eur J Immunol (2005) 35:3054-3063. | Demonstrates the use of ST2L and IL-18R in differentiating normal versus pre-eclamptic pregnancies. |
| Atherosclerotic Abdominal Aortic Aneurysm and the Interaction Between Autologous Human Plaque-Derived Vascular Smooth Muscle Cells, Type-1 NKT, and Helper T-Cells Chan, W.L. et al., Circ Res (2005) 96:675-683 | Use of Il-18R and ST2L in differentiating inflammatory cells in the presence of atherosclerotic plaques in Abdominal Aortic Aneurysm (AAA) |
| NKT cell subsets in infection and inflammation Chan WL, et al. Immun Lett (2003) 85:159-163 | Data demonstrating that ST2L and IL-18R could serve as important determinants of immune status in human diseases such as HIV, psoriasis, atherosclerosis |
| Regulation of ST2L expression on T helper (Th) type 2 cells Carter, R.W. et al., Eur. J. Immunol. (2001) 31:2979-2985 | Data providing mechanistic explanation for the selective expression of ST2L on Th2 cells |
| Human IL-18 Receptor and ST2L Are Stable and Selective markers for the Respective Type 1 and Type 2 Circulating Lymphocytes Chan WL, et al. J Immunol. 2001 Aug 1; 167(3):1238-44. | ST2L and IL-18R markers are stable cell surface markers serving as important determinants of the general immune status in human diseases, thereby useful as markers for therapeutic monitoring and intervention. |
How To Use
Application
- Use as a specific Th1/Tc1 marker.
- Suggested usage at 1/25 and detection with biotinylated goat anti-rabbit IgG followed by fluorochrome conjugated streptavidin for flow cytometry (FACS).
- Also suitable for cell sorting and immunohistochemistry using fluorochrome detection.