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Keratocan Antibody

Monoclonal Antibody to Keratocan, clone Ker-1
Catalog Number: 
100 ug

Monoclonal Antibody to Monoclonal Antibody to Keratocan, clone Ker-1 from MD Bioproducts

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Keratocan (KERA) monoclonal antibody (mouse, clone Ker-1) to detect keratocan.



Normal keratocan expression in adult tissues is limited to the corneal stroma and is considered a phenotypic marker for keratocytes. In keratocan knockout mice (Kera-/-) the corneal stroma is thinner, the cornea-iris angles are narrower and the collagen fibers of the corneal stroma are disorganized when compared to wild-type animals. In humans, mutations of the keratocan gene (KERA) are associated with the human disease called Cornea plana (CNA2). This disease is characterized by a flattening of the forward convex curvature of the cornea and has been associated with glaucoma. Ultimately, this leads to a decrease in light refraction. Present research is focused on using adult stem cells to regenerate tissue and corneal transparency within knockout mice. Additionally, understanding keratocan in the corneal inflammatory response is a topic of interest.

Related Terms/Symbols:

  • KERA
  • CNA2
  • Keratan sulfate proteoglycans (KSPGs)
  • O60938
  • KTN
  • SLRR2B




Clone: Ker-1


Host: Mouse


Isotype: IgM


Purity: Affinity purified on thiophilic column


Form: Liquid, 1 mL/vial


Concentration: 0.1 mg/mL


Storage: Store at -20°C. 


Specificity: This Keratocan antibody recognises a protein core epitope in human, bovine, porcine, mouse & chicken tissues.



How To Use

How To Use: 




  • Western Blot: recommended dilution 0.4 mg/mL
  • IHC



Technical Note

This epitope is best recognized after keratanase and keratanase II treatment/digestion

of section (IHC) or tissue extracts (for Western analyses). In some IHC tissue analyses,

chondroitinase treatment may also be used as this second enzyme treatment facilitates

antibody penetration into the tissue.