web monitor

Lumican, Antibody

Monoclonal Antibody to Lumican, clone Lum-1
Catalog Number: 
1042007
Qty/Size: 
100 ug

Monoclonal Antibody to Lumican, clone Lum-1 from MD Bioproducts

North America: 1-888-USMDBIO
International: +41-44 986 2628

Or you can order by using our online form
Have questions or need bulk? No problem, just ask.

Lumican (LUM) monoclonal antibody (mouse, clone Lum-1) to detect a protein epitope in lumican.

Overview

Overview: 

Lumican (LUM) is the major keratan sulfate proteoglycan of the cornea and it binds collagen fibrils. In noncorneal tissues, lumican is present as a low or nonsulfated glycoprotein and has been found in the aorta, cartilage, liver, skeletal muscle, kidney, pancreas, brain, placenta and lung. Complications of the cornea have been confirmed using lumican-null mice. These mice exhibit corneal opacity, skin fragility, and impaired collagen fibrillogenesis. More recent studies show lumican has an integral role in cell migration, adhesion and proliferation. The expression of lumican has also been examined in breast, pancreatic and colorectal cancer. The affect of lumican depends on the type of cancer as it has been shown to have both a positive and negative affect on tumor growth.


Related Terms/Symbols

  • LUM
  • LDC
  • SLRR2D
  • P51884
  • Lumican proteoglycan
  • major keratan sulfate proteoglycan

 

 

Data/Specifications

Data/Specifications: 

 

Clone: Lum-1

 

Host: Mouse

 

Isotype: IgM

 

Purity: Affinity purified on thiophilic column

 

Form: Liquid, 1 mL/vial

 

Concentration: 0.1 mg/mL

 

Storage: -20°C.

 

Specificity: This Lumican antibody recognises a protein epitope in lumican derived from human, bovine, porcine & mouse tissues.

Literature/Support

How To Use

How To Use: 

 

Applications

 

  • Western Blot: recommended dilution 0.2 mg/mL
  • IHC

 

 

Technical Notes

This epitope is best recognized after keratanase and keratanase II treatment/digestion

of section (IHC) or tissue extracts (for Western analyses). In some IHC tissue analyses,

chondroitinase treatment may also be used, as this second enzyme treatment facilitates

antibody penetration into the tissue.

Related Products