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Aggrecan

Chondroitinase generated C-4-S & DS Antibody

Catalog Number: 
1042009
Qty/Size: 
100 ug

monoclonal antibody to chondroitinase generated C-4-S & DS, clone 2B6 from MD Bioproducts

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Chondroitin-4-sulfate (C-4-S) monoclonal antibody that's also specific to dermatan-sulfate (DS) neoepitope (mouse, clone 2B6).

Overview

Overview: 

Monoclonal antibody to delta-unsaturated glucuronic acid adjacent to N-acetylgalactosamine- 4-sulphate in the non-reducing terminal dissacharide “stub” of 4-sulphated chondroitin sulfate that is produced after chondroitinase digestion of chondroitin-4- sulphate glycosaminoglycan chains (chondroitinase ABC or ACII) or dermatan sulphate glycosaminoglycan chains (chondroitinase ABC or chondroitinase B).

Related Terms/Symbols:

  • Chondroitin-4-sulfate
  • C-4-S
  • Dermatan-sulfate

Data/Specifications

Data/Specifications: 

Immunogen: Bovine nasal cartilage aggrecan that had been deglycosylated with chondroitinase ABC digestion; i.e. BNC (ABC) Core (see Couchman et al 1984 and Caterson et al 1985).

 

Clone: 2B6

 

Isotype: IgG

 

Host: Mouse

 

Purity: Affinity purified

 

Specificity: Chondroitin-4-sulphate (C-4-S) after treatment with Chondroitinase ABC or ACII. Dermatan sulphate (DS) neoepitope after treatment with Chondroitinase ABC or B.

 

Form: liquid

 

Storage: -20° C

Literature/Support

How To Use

How To Use: 

Applications

 

  • ELISA
  • Western Blot
  • Immunohistochemistry

 

 

Technical Notes

Pretreatment with Chondroitinase required. 1x10-3 U per 10 mg GAG at 37 °C for 1 hour.