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IL-18R

IL-18R Antibody

Polyclonal Antibody to human Interleukin-18 Receptor (IL-18R)
Catalog Number: 
201006
Qty/Size: 
0.5 mL

polyclonal antibody to human IL-18R from MD Bioproducts

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Interleukin-18 Receptor (IL-18R) polyclonal antibody (rabbit anti-human) specific for IL-18R on the surface of Th1/Tc1 cells.

Overview

Overview: 

Interleukin-18 receptor (IL-18R) is found to be expressed on memory T1 and T2 PBMC (peripheral blood memory leukocytes). The receptor is comprised of alpha and beta-chains that are encoded by the genes IL18R1 and IL18RAP. The IL-18R receptor mediates functions of the IL-18 cytokine including pro-inflammatory properties. The antibody can be used to understand the physiological and pathological functions of IL-18 responsiveness and for the study of signal transduction mechanisms. Furthermore, the antibody can be used as a marker to monitor lymphocyte subset changes in human disease.

 

Symbols/Alternate Terms:

 

  • IL18R1
  • IL18RAP

 

Data/Specifications

Data/Specifications: 

Form: 0.5 mL vial, supplied with 0.5 mL of pre-immune matched normal rabbit serum as control.

 

Specificity: Human Interleukin 18 Receptor, a cell surface marker present specifically on Th1/Tc1 cells.

 

Immunogen: A keyhole limpet haemocyanin-conjugated peptide to hlL-18R extracellular domain.

Literature/Support

Literature/Support: 

IL-18R Antibody Insert (PDF, 228 KB)

 

References/Citations:The IL-18R Antibody was used for:

Predominance of Th2 response in human abdominal aortic aneurysm: Mistaken identity for IL-4-producing NK and NKT cells?  Chan WL, et al. Cellular Immun (2005) 233:109-114

 

Application of ST2L and IL18R markers in absdominal aortic aneurysms
Changes in systemic type 1 and type 2 immunity in normal pregnancy and pre-eclampsia may be mediated by natural killer cells  Borzychowski, A.M. et al., Eur J Immunol (2005) 35:3054-3063. 

Demonstrates the use of ST2L and IL-18R in differentiating normal versus pre-eclamptic pregnancies.
Atherosclerotic Abdominal Aortic Aneurysm and the Interaction Between Autologous Human Plaque-Derived Vascular Smooth Muscle Cells, Type-1 NKT, and Helper T-Cells  Chan, W.L. et al., Circ Res (2005) 96:675-683

Use of Il-18R and ST2L in differentiating inflammatory cells in the presence of atherosclerotic plaques in Abdominal Aortic Aneurysm (AAA)
NKT cell subsets in infection and inflammation  Chan WL, et al. Immun Lett (2003) 85:159-163

Data demonstrating that ST2L and IL-18R could serve as important determinants of immune status in human diseases such as HIV, psoriasis, atherosclerosis

Regulation of ST2L expression on T helper (Th) type 2 cells  Carter, R.W. et al., Eur. J. Immunol. (2001) 31:2979-2985

Data providing mechanistic explanation for the selective expression of ST2L on Th2 cells
Human IL-18 Receptor and ST2L Are Stable and Selective markers for the Respective Type 1 and Type 2 Circulating Lymphocytes  Chan WL, et al. J Immunol. 2001 Aug 1; 167(3):1238-44.ST2L and IL-18R markers are stable cell surface markers serving as important determinants of the general immune status in human diseases, thereby useful as markers for therapeutic monitoring and intervention.



How To Use

How To Use: 

 

Application

 

  • Use as a specific Th1/Tc1 marker.
  • Suggested usage at 1/25 and detection with biotinylated goat anti-rabbit IgG followed by fluorochrome conjugated streptavidin for flow cytometry (FACS).
  • Also suitable for cell sorting and immunohistochemistry using fluorochrome detection.