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Lumican, Antibody

Monoclonal Antibody to Lumican, clone Lum-1
Catalog Number: 
100 ug

Monoclonal Antibody to Lumican, clone Lum-1 from MD Bioproducts

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Lumican (LUM) monoclonal antibody (mouse, clone Lum-1) to detect a protein epitope in lumican.



Lumican (LUM) is the major keratan sulfate proteoglycan of the cornea and it binds collagen fibrils. In noncorneal tissues, lumican is present as a low or nonsulfated glycoprotein and has been found in the aorta, cartilage, liver, skeletal muscle, kidney, pancreas, brain, placenta and lung. Complications of the cornea have been confirmed using lumican-null mice. These mice exhibit corneal opacity, skin fragility, and impaired collagen fibrillogenesis. More recent studies show lumican has an integral role in cell migration, adhesion and proliferation. The expression of lumican has also been examined in breast, pancreatic and colorectal cancer. The affect of lumican depends on the type of cancer as it has been shown to have both a positive and negative affect on tumor growth.

Related Terms/Symbols

  • LUM
  • LDC
  • SLRR2D
  • P51884
  • Lumican proteoglycan
  • major keratan sulfate proteoglycan






Clone: Lum-1


Host: Mouse


Isotype: IgM


Purity: Affinity purified on thiophilic column


Form: Liquid, 1 mL/vial


Concentration: 0.1 mg/mL


Storage: -20°C.


Specificity: This Lumican antibody recognises a protein epitope in lumican derived from human, bovine, porcine & mouse tissues.


How To Use

How To Use: 




  • Western Blot: recommended dilution 0.2 mg/mL
  • IHC



Technical Notes

This epitope is best recognized after keratanase and keratanase II treatment/digestion

of section (IHC) or tissue extracts (for Western analyses). In some IHC tissue analyses,

chondroitinase treatment may also be used, as this second enzyme treatment facilitates

antibody penetration into the tissue.

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