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IL-33 in asthma: application note using T1/ST2 antibody

IL-33 is mainly expressed by fibroblasts, epithelial cells and endothelial cells. It is the ligand for orphan receptor, ST2. IL-33-ST2 plays a dual role, in some cases promotes Th2 cells and in other cases exacerbates Th2 and mast cell mediated inflammatory diseases.