T1/ST2 Monoclonal Antibody, PE conjugated (PDF, product insert)
Understanding The Four Isoforms of ST2 (blog post)
Symowski, C., & Voehringer, D. (2019). Th2 cell?derived IL?4/IL?13 promote ILC2 accumulation in the lung by ILC2?intrinsic STAT6 signaling in mice. European Journal of Immunology.
Kobayashi, T., Voisin, B., Kennedy, E. A., Jo, J. H., Shih, H. Y., Truong, A., ... & Moro, K. (2019). Homeostatic Control of Sebaceous Glands by Innate Lymphoid Cells Regulates Commensal Bacteria Equilibrium. Cell, 176(5), 982-997
Moldaver, D. M., Bharhani, M. S., Rudulier, C. D., Wattie, J., Inman, M. D., & Larché, M. (2019). Induction of bystander tolerance and immune deviation after Fel d 1 peptide immunotherapy. Journal of Allergy and Clinical Immunology, 143(3), 1087-1099.
Lai, D., Tang, J., Chen, L., Fan, E. K., Scott, M. J., Li, Y., ... & Fan, J. (2018). Group 2 innate lymphoid cells protect lung endothelial cells from pyroptosis in sepsis. Cell death & disease, 9(3), 369.
Schneider, C., O’Leary, C. E., von Moltke, J., Liang, H. E., Ang, Q. Y., Turnbaugh, P. J., ... & Locksley, R. M. (2018). A Metabolite-Triggered Tuft Cell-ILC2 Circuit Drives Small Intestinal Remodeling. Cell.
Omata, Y., Frech, M., Primbs, T., Lucas, S., Andreev, D., Scholtysek, C., ... & Andreas, N. (2018). Group 2 Innate Lymphoid Cells Attenuate Inflammatory Arthritis and Protect from Bone Destruction in Mice. Cell reports, 24(1), 169-180.
References/Citations: | How the T1/ST2 Biotinylated antibody was used: |
Cutting Edge: Atopy Promotes Th2 Responses to Alloantigens and Increases the Incidence and Tempo of Corneal Allograft Rejection
Clay Beauregard et al., J. Immunol., Jun 2005; 174: 6577 - 6581. | Immunohistochemistry analysis to detect the presence of Th2 cells in four-micrometer cross sections of the eye. Eyes were obtained from C57/BL/6 and BALB/c mice. |
Predominance of Th2 response in human abdominal aortic aneurysm: Mistaken identity for IL-4-producing NK and NKT cells? Chan WL, et al. Cellular Immun (2005) 233:109-114 | Application of ST2L and IL18R markers in absdominal aortic aneurysms
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Changes in systemic type 1 and type 2 immunity in normal pregnancy and pre-eclampsia may be mediated by natural killer cells Borzychowski, A.M. et al., Eur J Immunol (2005) 35:3054-3063.
| Demonstrates the use of ST2L and IL-18R in differentiating normal versus pre-eclamptic pregnancies.
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Atherosclerotic Abdominal Aortic Aneurysm and the Interaction Between Autologous Human Plaque-Derived Vascular Smooth Muscle Cells, Type-1 NKT, and Helper T-Cells Chan, W.L. et al., Circ Res (2005) 96:675-683
| Use of Il-18R and ST2L in differentiating inflammatory cells in the presence of atherosclerotic plaques in Abdominal Aortic Aneurysm (AAA)
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NKT cell subsets in infection and inflammation Chan WL, et al. Immun Lett (2003) 85:159-163
| Data demonstrating that ST2L and IL-18R could serve as important determinants of immune status in human diseases such as HIV, psoriasis, atherosclerosis
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Regulation of ST2L expression on T helper (Th) type 2 cells Carter, R.W. et al., Eur. J. Immunol. (2001) 31:2979-2985
| Data providing mechanistic explanation for the selective expression of ST2L on Th2 cells
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| Human IL-18 Receptor and ST@L Are Stable and Selective markers for the Respective Type 1 and Type 2 Circulating Lymphocytes Chan WL, et al. J Immunol. 2001 Aug 1; 167(3):1238-44. | ST2L and IL-18R markers are stable cell surface markers serving as important determinants of the general immune status in human diseases, thereby useful as markers for therapeutic monitoring and intervention.
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