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The IL-33-ST2 pathway
Jul 19, 2011

ST2 (also known as T1) is a member of the IL-1 receptor family (IL-1R) and comes in at least three isoforms (membrane bound,...

Citation: identifying changes in cervical ECM early in pregnancy. Rabbit anti-mouse polyclonal antibody
Apr 25, 2011

A recent publication using rabbit anti-mouse polyclonal antibody for immunoblotting collagen extracted from cervical tissue of pregnant and non-pregnant mice. The aim of the study is to gain a...

Induce arthritis in C57 strains: 100% incidence, as little as 2 mg Antibody cocktail
Feb 1, 2011

C57Bl/6 is a common background for generating genetically modified strains for use in in vivo models of arthritis. While these strains are commonly used, they are also known for requiring larger amounts of induction reagents, present with...

Using the Collagen Antibody Induced Arthritis Model as an alternative to the K/Bxn model
Jan 10, 2011

K/BxN mice spontaneously develop a severe, chronic, progressive inflammatory arthritis at about 27 days of age. They develop auto-antibodies recognizing glucose-6-phosphate isomerase. Serum from these animals when transferred to recipient animals induce arthritis. The mechanism of action...

Choosing the right antibody when developing an ELISA (part 2)
Sep 21, 2010

Antibodies are key to an ELISA and provide the basis for the specificity and sensitivity of the assay. In a previous blog post, we discussed factors such as...

Using the anti-mouse citrullinated collagen type II antibody as a biomarker for RA.
Aug 20, 2010

The citrullination of proteins is a post-translational modification where peptidyl arginine residues are converted to peptidyl citrulline by a family of enzymes called peptidyl arginine deiminases (PADs). Citrullination can be found in multiple tissue types and has been shown to occur in both...

Isolating articular chondrocytes from cartilage for cell culture
Aug 9, 2010

Articular cartilage is located on bone surfaces within vertebral joints, and ensures a smooth and almost-frictionless surface for the movement of the bones within the joint. In osteoarthritis, the destruction of cartilage is the primary cause of pain and discomfort. For these reasons,...

ST2 Antibodies in Different Studies and Applications
Jul 23, 2010

Sometimes it’s just cool to see and read about the antibodies we offer being used by customers who have published their work. Listed below are bullet points that summarize how the ST2 antibodies are being used in different studies and applications. These were written after reading customers...

Measuring aggrecanase activity to identify potential therapeutics for osteoarthritis.
Jul 12, 2010

An increase in the activity of matrix metalloproteinases (MMPs) and aggrecanases contributes to the progression of osteoarthritis and the degradation of articular cartilage. Specifically, this degradation occurs at sites along aggrecan, the most abundant cartilage proteoglycan. These events...

Happy 4th of July!
Jul 1, 2010

Every year families and friends in the United States gather to celebrate the 4th of July, known as Independence Day. This weekend is commonly associated with fireworks, parades, cookouts, and other fun activities.

If you find yourself wondering what activity may keep the science side of...