Collagen Induced Arthritis

Disease Induction Reagents for CIA

The Collagen Induced Arthritis (CIA) model is a commonly used model as it shares immunological and pathological similarities to human rheumatoid arthritis (RA). Arthritis is initiated by intradermal injections of Collagen Type II (CII) emulsified in Complete Freund's Adjuvant (CFA). This causes an immune response generating antibodies to CII. Therefore there is both a T cell and B cell component to the pathology. This joint destruction in collagen-induced arthritis involves cartilage destruction, bone resorption, synovial hyperplasia and periarticular cell infiltration thereby sharing many similarities to human RA.

The quality of collagen and emulsion plays a critical role in disease incidence in the CIA model. MD Bioproducts provides highly-purified (>99%), quality collagen and adjuvants for induction in arthritis in in vivo models as well as for use in in vitro applications.

MD Bioproducts specializes in providing the highest quality collagen, particularly Collagen Type II, for use in disease induction studies, with a primary focus on arthritis research in preclinical settings. 

Highly Purified Immunization Grade Collagen Type II

Collagen Type II, Bovine, Lyophilized, MD Bioproducts
Bovine Collagen Type II,  Lyophilized 
SKU: 804001-Lyo
Size: 10mg
Format: Lyophilized
Immunization Grade Collagen type II (CII) protein, purified from fetal bovine articular cartilage. Can be reconstituted to desired concentration in acetic acid
Collagen Type II, Bovine, Soluble, MD Bioproducts
SKU: 804001-Sol
Size: 5mL (2mg/mL)
Format: Solution
Immunization Grade Collagen type II (CII) protein, purified from fetal bovine articular cartilage.
Collagen Type II, Chicken, Lyophilized, MD Bioproducts
SKU: 804002-Lyo
Size: 10mg
Format: Lyophilized
Highest quality (>99%) Collagen type II (CII) protein, purified from chicken sternum. Can be reconstituted to desired concentration in acetic acid
Collagen Type II, Chicken, Soluble, MD Bioproducts
SKU: 804002-Sol
Size: 5mL (2mg/mL)
Format: Solution
Highest quality (>99%) Collagen type II (CII) protein, purified from chicken sternum.

Complete & Incomplete Freund's Adjuvant

Complete Freund's Adjuvant, MD Bioproducts
SKU: 501009
Size: 5mL (4mg/mL)
Complete Freund's Adjuvant (CFA or FCA) is 4 mg/ml M. Tuberculosis (non-viable) in mineral oil. For in-vivo/in-vitro studies. Typically used for the boost of an immune response.
Incomplete Freund's Adjuvant, MD Bioproducts
SKU: 501011
Size: 5mL 
Incomplete Freund's Adjuvant (IFA or FIA) for booster injections. For in-vivo/in-vitro studies.