Calcitonin ELISA
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Calcitonin ELISA kit to measure calcitonin levels in human samples.
Overview
Calcitonin, a 32-amino-acid polypeptide, is secreted primarily by the thyroidal parafollicular C-cells. Its main biological effect is to inhibit osteoclastic bone resorption as well as playing a role in calcium and phosphorus metabolism in the bone and kidney. Calcitonin supresses resorption of bone by inhibiting the activity of osteoclasts releasing calcium and phosphorus into blood. In the kidney, calcium and phosphorus are prevented from being lost in urine by reabsorption in the kidney tubules. Calcitonin inhibits tubular reabsorption of these two ions, leading to increased rates of their loss in urine.
Related Terms/Symbols:
- CALCA gene
- CALCA1 gene
- P01258
- CALC_HUMAN
Data/Specifications
Species: human
Sample Type: serum
Sample Size: 100 uL
Standard Curve Range: 10 - 1000 pg/mL
Sensitivity: 1 pg/mL
Assay Length: 4.5 hrs
Literature/Support
Calcitonin ELISA Insert (PDF)
| References/Citations: | How the Calcitonin ELISA kit was used: |
| The RET Kinase Inhibitor NVP-AST487 Blocks Growth and Calcitonin Gene Expression through Distinct Mechanisms in Medullary Thyroid Cancer Cells Nagako Akeno-Stuart et al., Cancer Res., Jul 2007; 67: 6956 - 6964. | Measure the concentration of calcitonin in serum of athymic mice with human medullary carcinoma (cell line TT) xenografts and in TT cell-conditioned media. |