ST2L Human, Monoclonal Antibody, Biotinylated
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Human ST2L biotinylated monoclonal antibody (Clone B4E6) for the identification and purification of human type 2 lymphocyte (Th2) subsets
Overview
T1/ST2 (also known as IL-1 R4 or IL-33Ra) is a transmembrane glycoprotein expressed on mast cells and Th2 cells. It is a selective marker for both murine and human Th2 lymphocytes and plays a role in regulating inflammatory responses. IL-33 is a recently identified member of the IL-1 family of cytokines and is involved in Th2 mediated immune responses. IL-33 mediates its biological effects via T1/ST2 binding. The roles of IL-33 and T1/ST2 (IL-33Ra) have been investigated in many immune responses such as allergy, asthma, rheumatoid arthritis and osteoarthritis.
Data/Specifications
Clone: B4E6
IgG Subclass: IgG1
Form: The biotinylated antibody is supplied in PBS and purified over protein G-sepharose from concentrated tissue culture supernatant. The antibody is supplied with 0.1% sodium azide as preservative.
Specificity: This clone recognizes hST2L specifically on the cell surface of human type 2 (Th2, Tc2, NK2 and NKT2) but not type 1 lymphocytes.
Literature/Support
ST2L Monoclonal Antibody, Biotinylated (product insert)
Understanding The Four Isoforms of ST2 (blog post)
Gordon, E. D., Simpson, L. J., Rios, C. L., Ringel, L., Lachowicz-Scroggins, M. E., Peters, M. C., ... & Yuan, S. (2016). Alternative splicing of interleukin-33 and type 2 inflammation in asthma. Proceedings of the National Academy of Sciences, 113(31), 8765-8770.
| References/Citations: | The Antibody was used for: |
Predominance of Th2 response in human abdominal aortic aneurysm: Mistaken identity for IL-4-producing NK and NKT cells? Chan WL, et al. Cellular Immun (2005) 233:109-114
| Application of ST2L and IL18R markers in absdominal aortic aneurysms |
| Changes in systemic type 1 and type 2 immunity in normal pregnancy and pre-eclampsia may be mediated by natural killer cells Borzychowski, A.M. et al., Eur J Immunol (2005) 35:3054-3063. | Demonstrates the use of ST2L and IL-18R in differentiating normal versus pre-eclamptic pregnancies. |
| Atherosclerotic Abdominal Aortic Aneurysm and the Interaction Between Autologous Human Plaque-Derived Vascular Smooth Muscle Cells, Type-1 NKT, and Helper T-Cells Chan, W.L. et al., Circ Res (2005) 96:675-683 | Use of Il-18R and ST2L in differentiating inflammatory cells in the presence of atherosclerotic plaques in Abdominal Aortic Aneurysm (AAA) |
| NKT cell subsets in infection and inflammation Chan WL, et al. Immun Lett (2003) 85:159-163 | Data demonstrating that ST2L and IL-18R could serve as important determinants of immune status in human diseases such as HIV, psoriasis, atherosclerosis |
| Regulation of ST2L expression on T helper (Th) type 2 cells Carter, R.W. et al., Eur. J. Immunol. (2001) 31:2979-2985 | Data providing mechanistic explanation for the selective expression of ST2L on Th2 cells |
| Human IL-18 Receptor and ST@L Are Stable and Selective markers for the Respective Type 1 and Type 2 Circulating Lymphocytes Chan WL, et al. J Immunol. 2001 Aug 1; 167(3):1238-44. | ST2L and IL-18R markers are stable cell surface markers serving as important determinants of the general immune status in human diseases, thereby useful as markers for therapeutic monitoring and intervention. |
How To Use
Applications
- Flow cytometry
- FACS
- cell sorting
- immunohistochemistry with hybridoma culture supernatant