Aggrecan monoclonal antibody to N-terminal neoepitope DIPEN (mouse, clone BC-4).

Proteoglycans are categorized depending upon the nature of their glycosaminoglycan chains (chondroitin sulfate, dermatan sulfate, heparin sulphate and keratin sulfate) as well as characterized by size.

Aggrecan is a large aggregating proteoglycan of articular cartilage. It is found also in aorta tissue, discs, tendons and in the perineuronal net. It is responsible for hydrating cartilage, giving it compressibility and resilience during joint loading, thereby playing a major role in the normal function of cartilage. Depletion of glycosaminoglycan bearing aggrecan fragments is one of the earliest events in cartilage destruction.

References/Citations:

Dupuis, L. E., Nelson, E. L., Hozik, B., Porto, S. C., Rogers-DeCotes, A., Fosang, A., & Kern, C. B. (2019). Adamts5−/− mice exhibit altered aggrecan proteolytic profiles that correlate with ascending aortic anomalies. Arteriosclerosis, Thrombosis, and Vascular Biology, 39(10), 2067-2081.

Recapitulation of endochondrial bone formation using human adult mesenchymal stem cells as a paradigm for developmental engineering
Celeste Scotti et al., PNAS, April 2010; 107:7251-7256.
(Supporting Literature: Supporting Literature )Identification of a Novel HtrA1-susceptible Cleavage Site in Human Aggrecan: EVIDENCE FOR THE INVOLVEMENT OF HtrA1 IN AGGRECAN PROTEOLYSIS IN VIVO
Angela Chamberland et al., J. Biol. Chem., Oct 2009; 284: 27352 - 27359.