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T1/ST2 (IL-33R) Mouse, Monoclonal Antibody, FITC

Monoclonal Antibody to mouse T1/ST2 (IL-33R), clone DJ8, FITC
Catalog Number: 
0.5 mL

Monoclonal Antibody to mouse T1/ST2 (IL-33 R), clone DJ8 from MD Bioproducts

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Mouse T1/ST2 (IL-33 R) FITC conjugated monoclonal antibody (clone DJ8) for the identification and purification of murine T helper 2 (Th2) cells and all forms of murine mast cells.



T1/ST2 (also known as IL-1 R4 or IL-33Ra) is a transmembrane glycoprotein expressed on mast cells and Th2 cells. It is a selective marker for both murine and human Th2 lymphocytes and plays a role in regulating inflammatory responses. IL-33 is a recently identified member of the IL-1 family of cytokines and is involved in Th2 mediated immune responses. IL-33 mediates its biological effects via T1/ST2 binding. The roles of IL-33 and T1/ST2 (IL-33Ra) have been investigated in many immune responses such as allergy, asthma, rheumatoid arthritis and osteoarthritis.



Rat anti-Mouse T1/ST2 FITC-conjugated mAb

Clone: DJ8


Ig Subclass: IgG1 (light chain not isotyped)


Form: The antibody is supplied in PBS, with 0.1% sodium azide as preservative and purified over protein G-sepharose. The characteristics of each lot are tested by FACS analysis with bone marrow derived mast cells.


Specificity: This clone recognizes the membrane anchored murine T1M protein on the surface of T helper 2 cells and mast cells. T1M appears on fetal blood derived mast cell progenitors before they express the Fce RI, on IL-3-dependent bone marrow derived mast cells and on mature peritoneal mast cells. The antibody detects T1S protein consisting only of the extracellular portion of the protein, which is secreted from growth factor and proinflammatory cytokine-stimulated murine fibroblasts.


Immunogen: Eukariotically expressed fusion protein of mouse T1 ectodomain and human immunoglobulin Fc domain.



T1/ST2 Monoclonal Antibody, FITC (PDF, product insert)


Understanding The Four Isoforms of ST2 (blog post)


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Moldaver, D. M., Bharhani, M. S., Rudulier, C. D., Wattie, J., Inman, M. D., & Larché, M. (2019). Induction of bystander tolerance and immune deviation after Fel d 1 peptide immunotherapy. Journal of Allergy and Clinical Immunology143(3), 1087-1099.


Hiraishi, Y., Yamaguchi, S., Yoshizaki, T., Nambu, A., Shimura, E., Takamori, A., ... & Suzukawa, M. (2018). IL-33, IL-25 and TSLP contribute to development of fungal-associated protease-induced innate-type airway inflammation. Scientific reports8(1), 18052.


Zhou, Y., Wang, W., Zhao, C., Wang, Y., Wu, H., Sun, X., ... & Zhang, Y. (2018). Prostaglandin E2 Inhibits Group 2 Innate Lymphoid Cell Activation and Allergic Airway Inflammation Through E-Prostanoid 4-Cyclic Adenosine Monophosphate Signaling. Frontiers in immunology9, 501.


Bartemes, K., Chen, C. C., Iijima, K., Drake, L., & Kita, H. (2018). IL-33–responsive group 2 innate lymphoid cells are regulated by female sex hormones in the uterus. The Journal of Immunology200(1), 229-236.


Ball, D. H., Al-Riyami, L., Harnett, W., & Harnett, M. M. (2018). IL-33/ST2 signalling and crosstalk with FcεRI and TLR4 is targeted by the parasitic worm product, ES-62. Scientific reports8(1), 4497.


Ogasawara, T., Kohashi, Y., Ikari, J., Taniguchi, T., Tsuruoka, N., Watanabe-Takano, H., ... & Fukushima, Y. (2018). Allergic TH2 Response Governed by B-Cell Lymphoma 6 Function in Naturally Occurring Memory Phenotype CD4+ T Cells. Frontiers in immunology9, 750.


Moldaver, D. M., Bharhani, M. S., Rudulier, C. D., Wattie, J., Inman, M. D., & Larché, M. (2018). Induction of bystander tolerance and immune deviation following Fel d 1 Peptide Immunotherapy. Journal of Allergy and Clinical Immunology.


Shamji, M. H., Temblay, J. N., Cheng, W., Byrne, S. M., Macfarlane, E., Switzer, A. R., ... & Ashton-Rickardt, P. G. (2018). Antiapoptotic serine protease inhibitors contribute to survival of allergenic TH2 cells. Journal of Allergy and Clinical Immunology142(2), 569-581.


Califano, D., Furuya, Y., Roberts, S., Avram, D., McKenzie, A. N., & Metzger, D. W. (2018). IFN-γ increases susceptibility to influenza A infection through suppression of group II innate lymphoid cells. Mucosal immunology11(1), 209.


Masuda, C., Miyasaka, T., Kawakami, K., Inokuchi, J., Kawano, T., Dobashi‐Okuyama, K., ... & Ohno, I. (2018). Sex‐based differences in CD103+ dendritic cells promote female‐predominant Th2 cytokine production during allergic asthma. Clinical & Experimental Allergy48(4), 379-393.


Laman, J. D., Kooistra, S. M., & Clausen, B. E. (2017). Reproducibility issues: avoiding pitfalls in animal inflammation models. In Inflammation (pp. 1-17). Humana Press, New York, NY.


Nascimento, D. C., Melo, P. H., Pineros, A. R., Ferreira, R. G., Colón, D. F., Donate, P. B., ... & Borges, M. C. (2017). IL-33 contributes to sepsis-induced long-term immunosuppression by expanding the regulatory T cell population. Nature communications8, 14919.


Madouri, F., Chenuet, P., Beuraud, C., Fauconnier, L., Marchiol, T., Rouxel, N., ... & Marquant, Q. (2017). Protein kinase Cθ controls type 2 innate lymphoid cell and TH2 responses to house dust mite allergen. Journal of Allergy and Clinical Immunology139(5), 1650-1666.


Sjöberg, L. C., Nilsson, A. Z., Lei, Y., Gregory, J. A., Adner, M., & Nilsson, G. P. (2017). Interleukin 33 exacerbates antigen driven airway hyperresponsiveness, inflammation and remodeling in a mouse model of asthma. Scientific Reports7(1), 4219.


Sugita, J., Asada, Y., Ishida, W., Iwamoto, S., Sudo, K., Suto, H., ... & Ohno, T. (2017). Contributions of Interleukin‐33 and TSLP in a papain‐soaked contact lens‐induced mouse conjunctival inflammation model. Immunity, inflammation and disease5(4), 515-525.


Schwartz, C., Khan, A. R., Floudas, A., Saunders, S. P., Hams, E., Rodewald, H. R., ... & Fallon, P. G. (2017). ILC2s regulate adaptive Th2 cell functions via PD-L1 checkpoint control. Journal of Experimental Medicine, jem-20170051.


Imai, Y., Hosotani, Y., Ishikawa, H., Yasuda, K., Nagai, M., Jitsukawa, O., ... & Yamanishi, K. (2017). Expression of IL-33 in ocular surface epithelium induces atopic keratoconjunctivitis with activation of group 2 innate lymphoid cells in mice. Scientific Reports7(1), 10053.


Vonk, M. M., Wagenaar, L., Pieters, R. H., Knippels, L. M., Willemsen, L. E., Smit, J. J., ... & Garssen, J. (2017). The efficacy of oral and subcutaneous antigen-specific immunotherapy in murine cow’s milk-and peanut allergy models. Clinical and translational allergy7(1), 35.


Vonk, M. M., Diks, M. A., Wagenaar, L., Smit, J. J., Pieters, R. H., Garssen, J., ... & Knippels, L. M. (2017). Improved efficacy of oral immunotherapy using non-digestible oligosaccharides in a murine cow’s milk allergy model: a potential role for Foxp3+ regulatory T cells. Frontiers in immunology8, 1230.


Drube, S., Grimlowski, R., Deppermann, C., Fröbel, J., Kraft, F., Andreas, N., ... & Göpfert, C. (2017). The Neurobeachin-like 2 protein regulates mast cell homeostasis. The Journal of Immunology, ji1700556.


Zoltowska Nilsson, A. M., Lei, Y., Adner, M., & Nilsson, G. P. (2017). Mast cell-dependent IL-33/ST2 signaling is protective against the development of airway hyperresponsiveness in a house dust mite mouse model of asthma. American Journal of Physiology-Lung Cellular and Molecular Physiology314(3), L484-L492.


Dullaers, M., Schuijs, M. J., Willart, M., Fierens, K., Van Moorleghem, J., Hammad, H., & Lambrecht, B. N. (2017). House dust mite–driven asthma and allergen-specific T cells depend on B cells when the amount of inhaled allergen is limiting. Journal of Allergy and Clinical Immunology140(1), 76-88.


Xi, H., Katschke, K. J., Li, Y., Truong, T., Lee, W. P., Diehl, L., ... & Hackney, J. A. (2016). IL-33 amplifies an innate immune response in the degenerating retina. Journal of Experimental Medicine213(2), 189-207


Schulze, B., Piehler, D., Eschke, M., Heyen, L., Protschka, M., Köhler, G., & Alber, G. (2016). Therapeutic expansion of CD4+ FoxP3+ regulatory T cells limits allergic airway inflammation during pulmonary fungal infection. FEMS Pathogens and Disease74(4), ftw020.


de Miranda, S. M. N., Wilhelm, T., Huber, M., & Zorn, C. N. (2016). Differential Lyn-dependence of the SHIP1-deficient mast cell phenotype. Cell Communication and Signaling14(1), 12.


Vogel, K. U., Bell, L. S., Galloway, A., Ahlfors, H., & Turner, M. (2016). The RNA-binding proteins Zfp36l1 and Zfp36l2 enforce the thymic β-selection checkpoint by limiting DNA damage response signaling and cell cycle progression. The Journal of Immunology, 1600854.


Hams, E., Bermingham, R., Wurlod, F. A., Hogan, A. E., O’Shea, D., Preston, R. J., ... & Fallon, P. G. (2015). The helminth T2 RNase ω1 promotes metabolic homeostasis in an IL-33–and group 2 innate lymphoid cell–dependent mechanism. The FASEB Journal30(2), 824-835.


Burrows, K. E., Dumont, C., Thompson, C. L., Catley, M. C., Dixon, K. L., & Marshall, D. (2015). OX40 blockade inhibits house dust mite driven allergic lung inflammation in mice and in vitro allergic responses in humans. European journal of immunology45(4), 1116-1128.


Palomo, J., Reverchon, F., Piotet, J., Besnard, A. G., Couturier‐Maillard, A., Maillet, I., ... & Quesniaux, V. F. (2015). Critical role of IL‐33 receptor ST2 in experimental cerebral malaria development. European journal of immunology45(5), 1354-1365.


Heger, K., Kober, M., Rieß, D., Drees, C., de Vries, I., Bertossi, A., ... & Schmidt‐Supprian, M. (2015). A novel Cre recombinase reporter mouse strain facilitates selective and efficient infection of primary immune cells with adenoviral vectors. European journal of immunology45(6), 1614-1620.


Suzuki, M., Morita, R., Hirata, Y., Shichita, T., & Yoshimura, A. (2015). Spred1, a suppressor of the Ras–ERK pathway, negatively regulates expansion and function of group 2 innate lymphoid cells. The Journal of Immunology, 1500531.


Arshad, M. I., Guihard, P., Danger, Y., Noel, G., Le Seyec, J., Boutet, M. A., ... & Gascan, H. (2015). Oncostatin M induces IL-33 expression in liver endothelial cells in mice and expands ST2+ CD4+ lymphocytes. American Journal of Physiology-Gastrointestinal and Liver Physiology309(7), G542-G553.


Shim, D. H., Park, Y. A., Kim, M. J., Hong, J. Y., Baek, J. Y., Kim, K. W., ... & Hong, K. J. (2015). Pandemic influenza virus, pH 1N1, induces asthmatic symptoms via activation of innate lymphoid cells. Pediatric Allergy and Immunology26(8), 780-788.


Ahmed, A., & Koma, M. K. (2015). Interleukin‐33 Triggers B 1 Cell Expansion and Its Release of Monocyte/Macrophage Chemoattractants and Growth Factors. Scandinavian journal of immunology82(2), 118-124.


Wojno, E. T., Monticelli, L. A., Tran, S. V., Alenghat, T., Osborne, L. C., Thome, J. J., ... & Artis, D. (2015). The prostaglandin D 2 receptor CRTH2 regulates accumulation of group 2 innate lymphoid cells in the inflamed lung. Mucosal immunology8(6), 1313.


Zhao, J., Wei, J., Bowser, R. K., Traister, R. S., Fan, M. H., & Zhao, Y. (2015). Focal Adhesion Kinase–Mediated Activation of Glycogen Synthase Kinase 3β Regulates IL-33 Receptor Internalization and IL-33 Signaling. The Journal of Immunology, 194(2), 795-802.


Mathie, S. A., Dixon, K. L., Walker, S. A., Tyrrell, V., Mondhe, M., O'Donnell, V. B., ... & Lloyd, C. M. (2015). Alveolar macrophages are sentinels of murine pulmonary homeostasis following inhaled antigen challenge. Allergy, 70(1), 80-89.


Yu, X., Pappu, R., Ramirez-Carrozzi, V., Ota, N., Caplazi, P., Zhang, J., & Grogan, J. L. (2014). TNF superfamily member TL1A elicits type 2 innate lymphoid cells at mucosal barriers. Mucosal immunology, 7(3), 730-740.


Mirchandani, A. S., Besnard, A. G., Yip, E., Scott, C., Bain, C. C., Cerovic, V., ... & Liew, F. Y. (2014). Type 2 innate lymphoid cells drive CD4+ Th2 cell responses. The Journal of Immunology, 192(5), 2442-2448.


Hams, E., Armstrong, M. E., Barlow, J. L., Saunders, S. P., Schwartz, C., Cooke, G., ... & Fallon, P. G. (2014). IL-25 and type 2 innate lymphoid cells induce pulmonary fibrosis. Proceedings of the National Academy of Sciences, 111(1), 367-372.


Hams, E., Locksley, R. M., McKenzie, A. N., & Fallon, P. G. (2013). Cutting edge: IL-25 elicits innate lymphoid type 2 and type II NKT cells that regulate obesity in mice. The Journal of Immunology, 191(11), 5349-5353.


Kabata, H., Moro, K., Fukunaga, K., Suzuki, Y., Miyata, J., Masaki, K., ... & Asano, K. (2013). Thymic stromal lymphopoietin induces corticosteroid resistance in natural helper cells during airway inflammation. Nature communications, 4.


Nussbaum, J. C., Van Dyken, S. J., von Moltke, J., Cheng, L. E., Mohapatra, A., Molofsky, A. B., ... & Locksley, R. M. (2013). Type 2 innate lymphoid cells control eosinophil homeostasis. Nature, 502(7470), 245-248.


Maazi, H., Shirinbak, S., Boef, L. E., Fallarino, F., Volpi, C., Nawijn, M. C., & Oosterhout, A. J. M. (2013). Cytotoxic T lymphocyte antigen 4‐immunoglobulin G is a potent adjuvant for experimental allergen immunotherapy. Clinical & Experimental Immunology, 172(1), 113-120.


Elsen, L. W. J., Esch, B. C. A. M., Hofman, G. A., Kant, J., Heijning, B. J. M., Garssen, J., & Willemsen, L. E. M. (2013). Dietary long chain n‐3 polyunsaturated fatty acids prevent allergic sensitization to cow's milk protein in mice. Clinical & Experimental Allergy, 43(7), 798-810.


Maazi, H., Shirinbak, S., Boef, L. E., Fallarino, F., Volpi, C., Nawijn, M. C., & Oosterhout, A. J. M. (2013). Cytotoxic T lymphocyte antigen 4‐immunoglobulin G is a potent adjuvant for experimental allergen immunotherapy. Clinical & Experimental Immunology, 172(1), 113-120.


Halim, T. Y., MacLaren, A., Romanish, M. T., Gold, M. J., McNagny, K. M., & Takei, F. (2012). Retinoic-acid-receptor-related orphan nuclear receptor alpha is required for natural helper cell development and allergic inflammation. Immunity, 37(3), 463-474.


Zhao, J., Wei, J., Mialki, R. K., Mallampalli, D. F., Chen, B. B., Coon, T., ... & Zhao, Y. (2012). F-box protein FBXL19-mediated ubiquitination and degradation of the receptor for IL-33 limits pulmonary inflammation. Nature immunology, 13(7), 651-658.


Müller, U., Piehler, D., Stenzel, W., Köhler, G., Frey, O., Held, J., ... & Alber, G. (2012). Lack of IL-4 receptor expression on T helper cells reduces T helper 2 cell polyfunctionality and confers resistance in allergic bronchopulmonary mycosis. Mucosal immunology, 5(3), 299-310.


Halim, T. Y., Krass, R. H., Sun, A. C., & Takei, F. (2012). Lung natural helper cells are a critical source of Th2 cell-type cytokines in protease allergen-induced airway inflammation. Immunity, 36(3), 451-463.


Kim, H. Y., Chang, Y. J., Subramanian, S., Lee, H. H., Albacker, L. A., Matangkasombut, P., & Umetsu, D. T. (2012). Innate lymphoid cells responding to IL-33 mediate airway hyperreactivity independently of adaptive immunity. Journal of Allergy and Clinical Immunology, 129(1), 216-227.


Jiang, H. R., Milovanović, M., Allan, D., Niedbala, W., Besnard, A. G., Fukada, S. Y., ... & Liew, F. Y. (2012). IL‐33 attenuates EAE by suppressing IL‐17 and IFN‐γ production and inducing alternatively activated macrophages. European journal of immunology, 42(7), 1804-1814.


Monticelli, L. A., Sonnenberg, G. F., Abt, M. C., Alenghat, T., Ziegler, C. G., Doering, T. A. & Artis, D. (2011). Innate lymphoid cells promote lung-tissue homeostasis after infection with influenza virus. Nature immunology, 12(11), 1045-1054.


Al-Garawi, A., Fattouh, R., Botelho, F., Walker, T. D., Goncharova, S., Moore, C. L., & Jordana, M. (2011). Influenza A facilitates sensitization to house dust mite in infant mice leading to an asthma phenotype in adulthood. Mucosal immunology, 4(6), 682-694.


How the T1/ST2 FITC conjugated antibody was used:
Identification of Semaphorin 4B as a Negative Regulator of Basophil-Mediated Immune Responses.
Nakagawa, Y et al., J. Immunol. (2011) 186:2881
CD4+ Tcells isolated from mice were stained with FITC conjugated anti-T1/ST2 antibodies and cultured.
Contribution of IL-33 to induction and augmentation of experimental allergic conjuctivitis.
Matsuba-Kitamura S, et al., International Immunology, May 2010
Immunohistochemistry analysis to detect the expression of ST2 in isolated conjunctival tissue from mice eyes. Used frozen tissue sections and examined expression patterns using confocal microscopy.
Eosinophils are dispensable for allergic remodeling and immunity in a model of house dust mite-induced airway disease.
Fattouh R, et al. Am J Respir Crit Care Med. 2010 Aug 23.
Contribution of IL-33 to induction and augmentation of experimental allergic conjuctivitis.
Matsuba-Kitamura S, et al., International Immunology, May 2010
Immunohistochemistry analysis to detect the expression of ST2 in isolated conjunctival tissue from mice eyes. Used frozen tissue sections and examined expression patterns using confocal microscopy.
Interleukin-33 attenuates sepsis by enhancing neutrophil influx to the site of infection.
Alves-Filho J, et al. Nature Medicine., 2010; 16(6):2-7.
Flow cytometry analysis to determine the expression of ST2 in bone marrow neutrophils isolated from BALB/c mice.
Activin-A induces regulatory T cells that suppress T helper cell immune responses and protect from allergic airway disease.
Semitekolou M, et al. J. Exp. Med., 2009; 206(8):1769-85.
Flow cytometry analysis to determine the expression of T1/ST2 in cells isolated from lymph nodes of BALB/c mice.
IL-33 reduces the development of atherosclerosis
Ashley M. Miller et al., J. Exp. Med., Feb 2008; 205: 339 - 346.
Flow cytometry analysis to determine the level of ST2 expression in lymph node cells isolated from mice.
IL-1beta-driven ST2L expression promotes maturation resistance in rapamycin-conditioned dendritic cells.
Turnquist H, et al. Journ. Immunol., 2008; 181(1):62-72.
Flow cytometry analysis to detect the surface expression of ST2 in dendritic cells of mice. Analysis was performed using a LSR II flow cytometer and FlowJo software.
Osteopontin has a crucial role in allergic airway disease through regulation of dendritic cell subsets. Xanthou G, et al. Nature Medicine. 2007; 13(5):570-80
Flow cytometry analysis of T1/ST2 in isolated cells from draining lymph nodes of DO11.10 mice.
Soluble ST2 Blocks Interleukin-33 Signaling in Allergic Airway Inflammation
Hiroko Hayakawa et al., J. Biol. Chem., Sep 2007; 282: 26369 - 26380.
Flow cytometry analysis to quantify the expression of ST2L in splenocytes isolated from mice and in murine thymoma EL-4 cells.
Phenotypic differences between Th1 and Th17 cells and negative regulation of Th1 cell differentiation by IL-17
Susumu Nakae et al., J. Leukoc. Biol., May 2007; 81: 1258 - 1268.
Flow cytometry analysis to determine the expression of T1/ST2 on cells isolated from spleens of transgenic and wild-type mice.
Airway Epithelial STAT3 Is Required for Allergic Inflammation in a Murine Model of Asthma
Marina C. Simeone-Penney et al.,  J. Immunol., May 2007; 178: 6191 - 6199.
Flow cytometry analysis to determine the percentage of Th2 cells in the lungs of mice.
CCR4 is a key modulator of innate immune responses.
Ness T, et al. Journ. of immunol., 2006; 177(11): 7531-9.
Flow cytometry analysis to determine the expression of ST2 in peritoneal cells isolated from mice. Analysis was performed using a Beckman Coulter Cytomics FC 500 and FlowJo 6.3 software.

IFN- Induces Apoptosis in Developing Mast Cells
Meredith N. Mann-Chandler et al., J. Immunol., Sep 2005; 175: 3000 - 3005.

Flow cytometry analysis to quantify the expression of T1/ST2 in bone marrow cells isolated from femurs and tibia of B6129PF1/J female mice.

Identification of mast cell progenitors in adult mice
Ching-Cheng Chen et al.,  PNAS, Aug 2005; 102: 11408 - 11413.

Flow cytometry analysis to detect the surface expression of T1/ST2 on mast cell progenitors (MCP). MCPs were isolated from the bone marrow of mice.

Predominance of Th2 response in human abdominal aortic aneurysm: Mistaken identity for IL-4-producing NK and NKT cells?  Chan WL, et al. Cellular Immun (2005) 233:109-114

Application of ST2L and IL18R markers in absdominal aortic aneurysms
Changes in systemic type 1 and type 2 immunity in normal pregnancy and pre-eclampsia may be mediated by natural killer cells  Borzychowski, A.M. et al., Eur J Immunol (2005) 35:3054-3063. 
Demonstrates the use of ST2L and IL-18R in differentiating normal versus pre-eclamptic pregnancies.
Atherosclerotic Abdominal Aortic Aneurysm and the Interaction Between Autologous Human Plaque-Derived Vascular Smooth Muscle Cells, Type-1 NKT, and Helper T-Cells  Chan, W.L. et al., Circ Res (2005) 96:675-683
Use of Il-18R and ST2L in differentiating inflammatory cells in the presence of atherosclerotic plaques in Abdominal Aortic Aneurysm (AAA)
NKT cell subsets in infection and inflammation  Chan WL, et al. Immun Lett (2003) 85:159-163

Data demonstrating that ST2L and IL-18R could serve as important determinants of immune status in human diseases such as HIV, psoriasis, atherosclerosis
Regulation of ST2L expression on T helper (Th) type 2 cells  Carter, R.W. et al., Eur. J. Immunol. (2001) 31:2979-2985
Data providing mechanistic explanation for the selective expression of ST2L on Th2 cells
Human IL-18 Receptor and ST@L Are Stable and Selective markers for the Respective Type 1 and Type 2 Circulating Lymphocytes  Chan WL, et al. J Immunol. 2001 Aug 1; 167(3):1238-44.ST2L and IL-18R markers are stable cell surface markers serving as important determinants of the general immune status in human diseases, thereby useful as markers for therapeutic monitoring and intervention.


How To Use

How To Use: 

This antibody allows the identification and purification of murine T helper 2 cells and all forms of murine mast cells.




  • Flow cytometry
  • immunoprecipitation