Lubricin (PRG4) monoclonal antibody (mouse, clone 6A1) to detect superficial zone protein (SZP) from bovine articular cartilage and a non conformational epitope in the C terminus of lubricin. Clear-liquid. No preservatives. Concentration is 0.1 mg/mL.

Lubricin is processed from the same gene as superficial zone protein, the proteoglycan 4 gene (PRG4). Lubricin is synthesized by synovial fibroblasts and secreted into the synovial fluid where its role is to regulate the lubrication of diarthrodial joints. Additionally, it is found in the meniscus, ligaments and tendons. Mutations in the lubricin gene are associated with camptodactyly-arthropathy-coxa vara-pericarditis syndrome.

Related Terms/Symbols

• PRG4
• Proteoglycan 4
• SZP
• Articular superficial zone protein
• Megakaryocyte stimulating factor
• Pericarditis syndrome
• Q92954

References/Citations:

Seol, D., McCabe, D. J., Choe, H., Zheng, H., Yu, Y., Jang, K., ... & Martin, J. A. (2012). Chondrogenic progenitor cells respond to cartilage injury. Arthritis & Rheumatism, 64(11), 3626-3637.