Myelin Oligodendrocyte Glycoprotein (MOG 35-55), 25 mg
Purified myelin oligodendrocyte glycoprotein (MOG) for MOG-induced EAE models in mouse and rat. Multiple Sclerosis (MS) is a demyelinating disease of the central nervous system (CNS). The main characteristics of the...
Protein
3038001
Purified myelin oligodendrocyte glycoprotein (MOG) for MOG-induced EAE models in mouse and rat.
Multiple Sclerosis (MS) is a demyelinating disease of the central nervous system (CNS). The main characteristics of the disease are focal areas of demyelination and inflammation, however the pathogenesis is unclear. Although no animal model thus far establishes all facets of human MS, Experimental Autoimmune Encephalomyelitis (EAE) represents the model most studied for the disease. Initially brain homogenates were used as antigens for immunization. Today, myelin related proteins or peptides are used in the disease.
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Recent References:
Gauthier, T., Martin-Rodriguez, O., Chagué, C., Daoui, A., Ceroi, A., Varin, A., ... & Perruche, S. (2023). In vivo reprogramming of macrophages using pro-resolving factors to resolve experimental CNS inflammation.
Hansson, C., Lebrero-Fernández, C., Schön, K., Angeletti, D., & Lycke, N. (2023). Tr1 cell-mediated protection against autoimmune disease by intranasal administration of a fusion protein targeting cDC1 cells. Mucosal Immunology.
He, Y., Ge, C., Moreno-Giró, À., Xu, B., Beusch, C. M., Sandor, K., ... & Holmdahl, R. (2023). A subset of antibodies targeting citrullinated proteins confers protection from rheumatoid arthritis. Nature Communications, 14(1), 691.
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