Featured Products for Arthritis Research
Feb 17 , 2025
Collagen Antibody Induced Arthritis
The Collagen Antibody-Induced Arthritis model (CAIA) using ArthritoMab™ Antibody Cocktail is ideal for rapidly screening and evaluating anti-inflammatory therapeutic agents. It is also relevant for studying inflammatory mediators such as cytokines, chemokines, matrix metalloproteinases, and other factors such as the role of bacterial flora and their by-products in triggering and exacerbating arthritis.
Collagen-induced arthritis (CIA) in mice is widely used as an experimental model for rheumatoid arthritis (RA) in humans. CIA is mediated by autoantibodies, which bind to a particular region of type II collagen (CII). The ability to induce arthritis using this arthritogenic antibody cocktail provides an efficient protocol for the induction of antibody-mediated arthritis that can be used as a shorter, more synchronized alternative to the CIA model and the K/BxN model.
Antibody Cocktail
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ArthritoMab™ Antibody Cocktail for Balb/c, DBA/1, R10.R111
SKU: CIA-MAB-50
Size: 50mg
ArthritoMab™ Arthritis Inducing Antibody Cocktail is a cocktail of 4 arthritogenic monoclonal antibodies to collagen II (CII) used for inducing arthritis in the anti-Collagen Antibody Induced Arthritis (CAIA) model. It is an excellent alternative to both the K/BxN and CIA models. Induction is rapid and results in a synchronized, steady and controlled disease progression that exhibits histological similarities to the classic CIA model.
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ArthritoMab™ Antibody Cocktail for C57BL/, TG
SKU: CIA-MAB-2C
Size: 50mg
ArthritoMab™ Antibody Cocktail is a reformulated cocktail of 4 monoclonal antibodies for the induction of arthritis as an alternative to the widely used collagen-induced arthritis (CIA) model. Many transgenic strains of mice are on a C57BL/6 background. However this strain is refractory to arthritis induction either by CIA or CAIA. Traditionally to overcome this in the CAIA model an increased dose of antibody cocktail is given. This reformulated cocktail of antibodies is optimized for production of arthritis in C57BL/6, inducing arthritis with lower doses of antibody. This new formulation can also be used in other strains of mouse, which traditionally require greater amounts of cocktail.
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Collagen Induced Arthritis
The Collagen Induced Arthritis (CIA) model is a commonly used model as it shares immunological and pathological similarities to human rheumatoid arthritis (RA). Arthritis is initiated by intradermal injections of Collagen Type II (CII) emulsified in Complete Freund's Adjuvant (CFA). This causes an immune response generating antibodies to CII. Therefore there is both a T cell and B cell component to the pathology. This joint destruction in collagen-induced arthritis involves cartilage destruction, bone resorption, synovial hyperplasia and periarticular cell infiltration thereby sharing many similarities to human RA.
The quality of collagen and emulsion plays a critical role in disease incidence in the CIA model. MD Bioproducts provides highly-purified (>99%), quality collagen and adjuvants for induction in arthritis in in vivo models as well as for use in in vitro applications.
Highly Purified Immunization Grade Collagen Type II
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Bovine Collagen Type II, Lyophilized
SKU: 804001-Lyo
Size: 10mg
Format: Lyophilized
Immunization Grade Collagen type II (CII) protein, purified from fetal bovine articular cartilage. Can be reconstituted to desired concentration in acetic acid
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SKU: 804001-Sol
Size: 5mL (2mg/mL)
Format: Solution
Immunization Grade Collagen type II (CII) protein, purified from fetal bovine articular cartilage.
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SKU: 804002-Lyo
Size: 10mg
Format: Lyophilized
Highest quality (>99%) Collagen type II (CII) protein, purified from chicken sternum. Can be reconstituted to desired concentration in acetic acid
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SKU: 804002-Sol
Size: 5mL (2mg/mL)
Format: Solution
Highest quality (>99%) Collagen type II (CII) protein, purified from chicken sternum.
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Complete & Incomplete Freund's Adjuvant
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SKU: 501009
Size: 5mL (4mg/mL)
Complete Freund's Adjuvant (CFA or FCA) is 4 mg/ml M. Tuberculosis (non-viable) in mineral oil. For in-vivo/in-vitro studies. Typically used for the boost of an immune response.
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SKU: 501011
Size: 5mL
Incomplete Freund's Adjuvant (IFA or FIA) for booster injections. For in-vivo/in-vitro studies.
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