Programmed cell death-1 (PD-1) is a key immunosuppressive molecule with two known ligands, PD-L1 and PD-L2. PD-L2 (also known as B7-DC or CD273), encoded by the PDCD1LG2 gene, plays a role in the negative regulation of the adaptive immune response as an immune checkpoint receptor ligand. Both PD-L1 and PD-L2 interact with PD-1 to modulate immune responses, making them significant targets in immunotherapy studies aimed at enhancing anti-tumor activity.

Abbreviations:

bA574F11.2, Butyrophilin B7-DC, PDCD1LG2, Btdc, PDCD1 ligand 2, PD-L2, Programmed death ligand 2, PDL2, PD-1 ligand 2, B7-DC, CD273, CD273, PDCD1L2, PD-L2.