ACC1, Monoclonal Antibody, 100ug
This antibody binds ACC1 to the citrullinated triple-helical collagen type II (CII) epitope (position 359-369), the C1 epitope. The ACC1 antibody recognizes the second citrulline at position 365 in mouse Collagen...
Antibodies
1061003
This antibody binds ACC1 to the citrullinated triple-helical collagen type II (CII) epitope (position 359-369), the C1 epitope. The ACC1 antibody recognizes the second citrulline at position 365 in mouse Collagen Type II. The antibody binds to flexible triple-helical Collagen Type II determinants and many citrullinated CII peptides and was found to cross-react with several non-citrullinated epitopes on native Collagen Type II. It cross-reacts with mouse and human.
Citrullination of proteins is a post-translational modification in which arginine is converted into citrulline by a family of enzymes called peptidylarginine deiminases (PADs). Proteins are susceptible to citrullination during inflammatory processes, and an autoantibody response to citrullinated proteins is a hallmark of Rheumatoid Arthritis.
Synonyms:
COL2A1, Collagen Type II, Collagen alpha-1(II) chain, CII, Col II, citrullinated CII; citrullinated Col II; citrullinated proteins.
The Mouse Anti-citrullinated COL2A1 Antibody clone ACC1 binds to the triple helical C1 epitope on collagen II when citrullinated. Binding to collagen type II epitopes was determined in bead-based flow immunoassay as median fluorescence intensity (MFI).
References:
1. Uysal H, Bockermann R, Nandakumar KS, Sehnert B, Bajtner E, Engström A, Serre G, Burkhardt H, Thunnissen MM, Holmdahl R. Structure and pathogenicity of antibodies specific for citrullinated collagen type II in experimental arthritis. J Exp Med. 2009 Feb 16;206(2):449-62.
2. Ge C, Tong D, Liang B, Lönnblom E, Schneider N, Hagert C, Viljanen J, Ayoglu B, Stawikowska R, Nilsson P, Fields GB, Skogh T, Kastbom A, Kihlberg J, Burkhardt H, Dobritzsch D, Holmdahl R. Anti-citrullinated protein antibodies cause arthritis by cross-reactivity to joint cartilage. JCI Insight. 2017 Jul 6;2(13):e93688.
Product Insert (PDF) - Informational use only. Please refer to insert included with product.
Data/Specifications:
- Clone: ACC1
- Host/Isotype: Mouse IgG2a, k
- Immunogen: B10.RIII Cia5 congenic mouse immunized with Bovine Collagen Type II
- Species Cross-Reactivity: Mouse, Human
- Form: This antibody is soluble and supplied in PBS.
- Application: Immunohistochemistry (IHC), ELISA, bead-based multiplex immunoassay
- Suggested Dilution: It is recommended that the user determine the optimal dilution for their application. The typical starting working dilutions are for IHC 1:100 and ELISA 1:200-1:500.
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