ACC4 (IgG2b), Monoclonal Antibody, 100ug
This antibody is an anti-citrullinated protein antibody (ACPA) that on Collagen alpha-1 (II) chain binds specifically to citrullinated C1 epitope on alpha-chain (position 359–369). It cross-reacts with mouse, bovine, and potentially...
Antibodies
1061005
This antibody is an anti-citrullinated protein antibody (ACPA) that on Collagen alpha-1 (II) chain binds specifically to citrullinated C1 epitope on alpha-chain (position 359–369). It cross-reacts with mouse, bovine, and potentially human.
Citrullination of proteins is a post-translational modification in which arginine is converted into citrulline by a family of enzymes called peptidylarginine deiminases (PADs). Proteins are susceptible to citrullination during inflammatory processes, and an autoantibody response to citrullinated proteins is a hallmark of Rheumatoid Arthritis.
Synonyms:
COL2A1, Collagen Type II, Collagen alpha-1(II) chain, CII, Col II, citrullinated CII; citrullinated Col II; citrullinated proteins.
References:
1. He, Y., Ge, C., Moreno-Giró, À. et al. A subset of antibodies targeting citrullinated proteins confers protection from rheumatoid arthritis. Nat Commun 14, 691 (2023).
2. Uysal H, Bockermann R, Nandakumar KS, Sehnert B, Bajtner E, Engström A, Serre G, Burkhardt H, Thunnissen MM, Holmdahl R. Structure and pathogenicity of antibodies specific for citrullinated collagen type II in experimental arthritis. J Exp Med. 2009 Feb 16;206(2):449-62.
Product Insert (PDF) - Informational use only. Please refer to insert included with product.
Data/Specifications:
- Clone: ACC4
- Host/Isotype: Mouse IgG2b, k
- Immunogen: Generated by immunization of DBA/1 or (B10.Q × DBA/1) F1 mice with Protein- arginine deiminase type-4 (PAD4) -treated triple-helical CII peptides containing T and B cell epitopes.
- Species Cross-Reactivity: Mouse, Human, potentially Human
- Form: This antibody is soluble and supplied in PBS.
- Application: Immunohistochemistry (IHC), in-vivo functional studies such Collagen- Induced Arthritis (CIA) , and evoked pain-behavior
- Suggested Dilution: It is recommended that the user determine the optimal dilution for their application. The typical starting working dilutions are for IHC 1:100.
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