Cartilage Oligomeric Matrix Protein (COMP) , Monoclonal Antibody (Clone 15A11), 100ug

This antibody binds to the fourth EGF (Epithelial Growth Factor) -like domain of mouse COMP, comprising residues 232–252, called the P6 epitope. Cartilage Oligomeric Matrix Protein (COMP) is a disulfide-linked pentameric...

Antibodies

1061007

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For research use only. Not for use in diagnostic procedures.

This antibody binds to the fourth EGF (Epithelial Growth Factor) -like domain of mouse COMP, comprising residues 232–252, called the P6 epitope.

Cartilage Oligomeric Matrix Protein (COMP) is a disulfide-linked pentameric proteoglycan primarily found in cartilage, but also present in other joint tissues such as meniscus, tendon, synovial fibroblasts, and osteoblasts. As a member of the thrombospondin family, COMP stimulates type II collagen fibril formation. It is released into the blood when cartilage is damaged, making it a valuable biomarker for predicting cartilage destruction in inflammatory joint diseases like rheumatoid arthritis (RA) and osteoarthritis (OA).

Synonyms:
Cartilage Oligomeric Matrix Protein, COMP

 

Monoclonal Antibody to COMP (Clone 15A11) Cartilage Oligomeric Matrix Protein, Affinity Purified

The mouse monoclonal anti-Cartilage Oligomeric Matrix Protein (COMP) antibody clone 15A11 binds to the fourth EGF (Epithelial Growth Factor) -like domain of murine COMP, comprising residues 232– 252, called the P6 epitope. Binding to recombinant human COMP was determined in enzyme linked immunosorbent assay (ELISA) as absorbance at 405nm.

 

References:

1. Geng H, Nandakumar KS, Pramhed A, Aspberg A, Mattsson R, Holmdahl R. Cartilage oligomeric matrix protein specific antibodies are pathogenic. Arthritis Res Ther. 2012 Aug 20;14(4):R191.

2. Li Y, Tong D, Liang P, Lönnblom E, Viljanen J, Xu B, Nandakumar KS, Holmdahl R. Cartilage-binding antibodies initiate joint inflammation and promote chronic erosive arthritis. Arthritis Res Ther. 2020 May 24;22(1):120.

Product Insert (PDF) - Informational use only. Please refer to insert included with product.

Data/Specifications:

  • Clone: 15A11
  • Host/Isotype: Mouse IgG1, k
  • Immunogen: Rat COMP
  • Species Cross-Reactivity: Mouse, Rat, Human
  • Form: This antibody is soluble and supplied in PBS.
  • Application: Immunohistochemistry (IHC), in-vivo functional assays.
  • Suggested Dilution: It is recommended that the user determine the optimal dilution for their application. The typical starting working dilutions are for IHC 1:100.

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