Collagen Type IV polyclonal antibody (rabbit anti-mouse) purified from rabbits injected with type IV collagen that was extracted/purified from mouse tumor tissues. IgG fraction, freeze-dried (0.5 ml)

Type IV collagen (CIV) is a major structural component of the basal lamina that assembles as a sheetlike network in the underlying extracellular space of all epithelial cells and tubes. The basal lamina separates the epithelia from the underlying connective tissue. There are several different isoforms of type IV collagen, but all are composed in a triple helical structure. The different isoforms are synthesized from six genes: COL4A1, COL4A2, COL4A3, COL4A4, COL4A5 and COL4A6. Type 1V collagens are considerably more flexible than the fibrillar type collagens. Mutations in genes associated with type IV collagen are associated with Alport and Goodpasture syndrome.

References/Citations:

Lu, C. L., Ortmeier, S., Brudvig, J., Moretti, T., Cain, J., Boyadjiev, S. A., ... & Kim, J. (2022). Collagen has a unique SEC24 preference for efficient export from the endoplasmic reticulum. Traffic, 23(1), 81-93.

Belle, M., Godefroy, D., Couly, G., Malone, S. A., Collier, F., Giacobini, P., & Chédotal, A. (2017). Tridimensional visualization and analysis of early human development. Cell, 169(1), 161-173.