This antibody (clone L10D9) binds to the triple-helical D3 epitope on collagen XI, which is shared with Collagen type II. The antibody binds to both Collagen Type XI (CXI) and Collagen Type II (CII), and CII is equally strong, with a specific binding for the D3 epitope region of the COL2A1 chain1. It cross-reacts with mouse and human.

Collagen type XI is a minor fibrillar collagen that plays a crucial role in cartilage organization and structural integrity. It is a component of the extracellular matrix that regulates collagen fibril diameter and cartilage development. In mouse models of arthritis, such as collagen- induced and spontaneous arthritis models, collagen type XI is studied for its involvement in cartilage degradation and joint pathology. Understanding the role of collagen type XI in these models helps researchers explore its contribution to the progression of arthritis, providing insights into potential therapeutic targets for joint diseases.