Lubricin Antibody, Native Bovine, 100 ug

Lubricin (PRG4) monoclonal antibody (mouse, clone 3A4) to detect the native form of bovine lubricin. Does not recognize reduced or denatured lubricin.   Lubricin is processed from the same gene as superficial...

Antibodies

1042011

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Lubricin (PRG4) monoclonal antibody (mouse, clone 3A4) to detect the native form of bovine lubricin. Does not recognize reduced or denatured lubricin.

 

Lubricin is processed from the same gene as superficial zone protein, the proteoglycan 4 gene (PRG4). Lubricin is synthesized by synovial fibroblasts and secreted into the synovial fluid where its role is to regulate the lubrication of diarthrodial joints. Additionally, it is found in the meniscus, ligaments and tendons of our body. Mutations in the lubricin gene are associated with camptodactyly-arthropathy-coxa vara-pericarditis syndrome.

Related Terms/Symbols

  • PRG4
  • Proteoglycan 4
  • SZP
  • Articular superficial zone protein
  • Megakaryocyte stimulating factor
  • Pericarditis syndrome
  • Q92954

 

References/Citations:

Wu, Y., Yang, Z., Denslin, V., Ren, X., Lee, C. S., Yap, F. L., & Lee, E. H. (2020). Repair of Osteochondral Defects With Predifferentiated Mesenchymal Stem Cells of Distinct Phenotypic Character Derived From a Nanotopographic Platform. The American Journal of Sports Medicine, 0363546520907137. 

Parreno, J., Bianchi, V. J., Sermer, C., Regmi, S. C., Backstein, D., Schmidt, T. A., & Kandel, R. A. (2018). Adherent agarose mold cultures: An in vitro platform for multifactorial assessment of passaged chondrocyte redifferentiation. Journal of Orthopaedic Research®, 36(9), 2392-2405.

Warnecke, D., Schild, N. B., Klose, S., Joos, H., Brenner, R. E., Kessler, O., ... & Dürselen, L. (2017). Friction properties of a new silk fibroin scaffold for meniscal replacement. Tribology international, 109, 586-592.

Pallante-Kichura, A. L., Chen, A. C., Temple-Wong, M. M., Bugbee, W. D., & Sah, R. L. (2013). In vivo efficacy of fresh versus frozen osteochondral allografts in the goat at 6 months is associated with PRG4 secretion. Journal of Orthopaedic Research, 31(6), 880-886.

 

Product Insert (PDF) - Informational use only. Please refer to insert included with product.

Data/Specifications: 

  • Immunogen: Bovine Supericial Zone Protein (SZP)
  • Clone: 3A4
  • Isotype: IgG
  • Host: Mouse
  • Purity: Affinity purified
  • Specificity: Native Bovine Lubricin (SZP, PRG4). Does not recognize reduced or denatured lubricin.
  • Form: Liquid
  • Storage: -20° C