Mouse T1/ST2 (IL-33 R) monoclonal antibody (Clone: DJ8, Host / Isotype Subclass: Rat IgG1, light chain not isotyped) for the identification and purification of murine T helper 2 (Th2) cells and all forms of murine mast cells.

T1/ST2 (also known as IL-1 R4 or IL-33Ra) is a transmembrane glycoprotein expressed on mast cells and Th2 cells. It is a selective marker for murine Th2 lymphocytes and plays a role in regulating inflammatory responses. IL-33 is a recently identified member of the IL-1 family of cytokines and is involved in Th2 mediated immune responses. IL-33 mediates its biological effects via T1/ST2 binding. The roles of IL-33 and T1/ST2 (IL-33Ra) have been investigated in many immune responses such as allergy, asthma, rheumatoid arthritis and osteoarthritis.

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IL-33 induces IL-13-dependent cutaneous fibrosis.
Rankin A, et al. Journ. of Immunol., 2010; 184(3):1526-35.

IL-33 Enhances Lipopolysaccharide-Induced Inflammatory Cytokine Production from Mouse Macrophages by Regulating Lipopolysaccharide Receptor Complex
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Interleukin-1 receptor-related protein ST2 suppresses the initial stage of bleomycin-induced lung injury N. Mato et al., Eur. Respir. J., Jun 2009; 33: 1415 - 1428.

IL-1 receptor accessory protein and ST2 comprise the IL-33 receptor complex.
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