Cartilage Oligomeric Matrix Protein (COMP), Monoclonal Antibody (Clone 16B5), 100ug
This antibody binds to the coiled-coil domain or pentamer COMP. It cross-reacts with mouse, rat and human. Cartilage Oligomeric Matrix Protein (COMP) is a disulfide-linked pentameric proteoglycan primarily found in cartilage,...
Antibodies
1061008
This antibody binds to the coiled-coil domain or pentamer COMP. It cross-reacts with mouse, rat and human.
Cartilage Oligomeric Matrix Protein (COMP) is a disulfide-linked pentameric proteoglycan primarily found in cartilage, but also present in other joint tissues such as meniscus, tendon, synovial fibroblasts, and osteoblasts. As a member of the thrombospondin family, COMP
stimulates type II collagen fibril formation. It is released into the blood when cartilage is damaged, making it a valuable biomarker for predicting cartilage destruction in inflammatory joint diseases like rheumatoid arthritis (RA) and osteoarthritis (OA).
Synonyms:
Cartilage Oligomeric Matrix Protein, COMP
16B5 binds to COMP (hCOMP, recombinant human COMP) but not to denatured COMP. Binding was determined in bead-based flow immunoassay as median fluorescence intensity (MFI). Bovine serum albumin (BSA) was used as the negative control.
References:
1. Geng H, Nandakumar KS, Pramhed A, Aspberg A, Mattsson R, Holmdahl R. Cartilage oligomeric matrix protein specific antibodies are pathogenic. Arthritis Res Ther. 2012 Aug 20;14(4):R191.
2. Geng H, Nandakumar KS, Xiong L, Jie R, Dong J, Holmdahl R. Incomplete B cell tolerance to cartilage oligomeric matrix protein in mice. Arthritis Rheum. 2013 Sep;65(9):2301-9.
Product Insert (PDF) - Informational use only. Please refer to insert included with product.
Data/Specifications:
- Clone: 16B5
- Host/Isotype: Mouse IgG1, k
- Immunogen: Rat COMP
- Species Cross-Reactivity: Mouse, Rat, Human
- Form: This antibody is soluble and supplied in PBS.
- Application: Immunohistochemistry (IHC), ELISA
- Suggested Dilution: It is recommended that the user determine the optimal dilution for their application. The typical starting working dilutions are for IHC 1:100, ELISA 1:200-1:500.
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