ST2L Human, Monoclonal Antibody, Biotinylated, 200 uL
Human ST2L biotinylated monoclonal antibody (Clone: B4E6, Host / Isotype Subclass: Mouse IgG1), for the identification and purification of human type 2 lymphocyte (Th2) subsets. T1/ST2 (also known as IL-1 R4 or...
Human ST2L biotinylated monoclonal antibody (Clone: B4E6, Host / Isotype Subclass: Mouse IgG1), for the identification and purification of human type 2 lymphocyte (Th2) subsets.
T1/ST2 (also known as IL-1 R4 or IL-33Ra) is a transmembrane glycoprotein expressed on mast cells and Th2 cells. It is a selective marker for human Th2 lymphocytes and plays a role in regulating inflammatory responses. IL-33 is a recently identified member of the IL-1 family of cytokines and is involved in Th2 mediated immune responses. IL-33 mediates its biological effects via T1/ST2 binding. The roles of IL-33 and T1/ST2 (IL-33Ra) have been investigated in many immune responses such as allergy, asthma, rheumatoid arthritis and osteoarthritis.
Gordon, E. D., Simpson, L. J., Rios, C. L., Ringel, L., Lachowicz-Scroggins, M. E., Peters, M. C., ... & Fahy, J. V. (2016). Alternative splicing of interleukin-33 and type 2 inflammation in asthma. Proceedings of the National Academy of Sciences, 113(31), 8765-8770.
Chan, W. L., Pejnovic, N., Liew, T. V., & Hamilton, H. (2005). Predominance of Th2 response in human abdominal aortic aneurysm: mistaken identity for IL-4-producing NK and NKT cells?. Cellular immunology, 233(2), 109-114.
Borzychowski, A. M., Croy, B. A., Chan, W. L., Redman, C. W., & Sargent, I. L. (2005). Changes in systemic type 1 and type 2 immunity in normal pregnancy and pre‐eclampsia may be mediated by natural killer cells. European journal of immunology, 35(10), 3054-3063.
Chan, W. L., Pejnovic, N., Hamilton, H., Liew, T. V., Popadic, D., Poggi, A., & Khan, S. M. (2005). Atherosclerotic abdominal aortic aneurysm and the interaction between autologous human plaque-derived vascular smooth muscle cells, type 1 NKT, and helper T cells. Circulation research, 96(6), 675-683.
Chan, W. L., Pejnovic, N., Liew, T. V., Lee, C. A., Groves, R., & Hamilton, H. (2003). NKT cell subsets in infection and inflammation. Immunology letters, 85(2), 159-163.
Carter, R. W., Sweet, M. J., Xu, D., Klemenz, R., Liew, F. Y., & Chan, W. L. (2001). Regulation of ST2L expression on T helper (Th) type 2 cells. European journal of immunology, 31(10), 2979-2985.
Chan, W. L., Pejnovic, N., Lee, C. A., & Al-Ali, N. A. (2001). Human IL-18 receptor and ST2L are stable and selective markers for the respective type 1 and type 2 circulating lymphocytes. The Journal of Immunology, 167(3), 1238-1244.
Product Insert (PDF) - Informational use only. Please refer to insert included with product.
- Clone: B4E6
- Host / Isotype Subclass: Mouse IgG1
- Form: The biotinylated antibody is supplied in PBS and purified over protein G-sepharose from concentrated tissue culture supernatant. The antibody is supplied with 0.1% sodium azide as preservative.
- Specificity: This clone recognizes hST2L specifically on the cell surface of human type 2 (Th2, Tc2, NK2 and NKT2) but not type 1 lymphocytes