Complete Freund's Adjuvant, 4 mg/mL (5 mL)
Complete Freund's Adjuvant (CFA or FCA) is 4 mg/ml M. Tuberculosis (non-viable) in mineral oil. For in-vivo/in-vitro studies. Typically used for the boost of an immune response. Complete Freund's Aduvant (CFA or...
Reagent
501009
Complete Freund's Adjuvant (CFA or FCA) is 4 mg/ml M. Tuberculosis (non-viable) in mineral oil. For in-vivo/in-vitro studies. Typically used for the boost of an immune response.
Complete Freund's Aduvant (CFA or FCA) is widely used in immunological research for the preparation of antigen-adjuvant emulsions in laboratory animal studies. CFA contains cell wall components of heat killed Mycobacterium tuberculosis and is often used for the initial injection that stimulates an enhanced immune response.
References/Citations:
Harnett, M. M., Doonan, J., Tarafdar, A., Pineda, M. A., Duncombe-Moore, J., Buitrago, G., Pan, P., Hoskisson, P. A., Selman, C., & Harnett, W. (2024). The parasitic worm product ES-62 protects against collagen-induced arthritis by resetting the gut-bone marrow axis in a microbiome-dependent manner. Frontiers in tropical diseases, 4, fitd.2023.1334705. https://doi.org/10.3389/fitd.2023.1334705
Malcolm, J., Nyirenda, M. H., Brown, J. L., Adrados-Planell, A., Campbell, L., Butcher, J. P., Glass, D. G., Piela, K., Goodyear, C. S., Wright, A. J., McInnes, I. B., Millington, O. R., & Culshaw, S. (2023). C-terminal citrullinated peptide alters antigen-specific APC:T cell interactions leading to breach of immune tolerance. Journal of autoimmunity, 135, 102994.
Libánská, A., Randárová, E., Skoroplyas, S., Bartoš, M., Luňáčková, J., Lager, F., Renault, G., Scherman, D., & Etrych, T. (2023). Size-switchable polymer-based nanomedicines in the advanced therapy of rheumatoid arthritis. Journal of controlled release : official journal of the Controlled Release Society, 353, 30–41.
Hansson, C., Lebrero-Fernández, C., Schön, K., Angeletti, D., & Lycke, N. (2023). Tr1 cell-mediated protection against autoimmune disease by intranasal administration of a fusion protein targeting cDC1 cells. Mucosal Immunology.
Lu, C. L., Ortmeier, S., Brudvig, J., Moretti, T., Cain, J., Boyadjiev, S. A., ... & Kim, J. (2022). Collagen has a unique SEC24 preference for efficient export from the endoplasmic reticulum. Traffic, 23(1), 81-93.
Wang, Y., Pan, P., Khan, A., Çil, Ç., & Pineda, M. A. (2022). Synovial Fibroblast Sialylation Regulates Cell Migration and Activation of Inflammatory Pathways in Arthritogenesis. Frontiers in Immunology, 13.
Simpkins, D. A., Downton, P., Gray, K. J., Dickson, S. H., Maidstone, R. J., Konkel, J. E., ... & Gibbs, J. E. (2022). Consequences of collagen induced inflammatory arthritis on circadian regulation of the gut microbiome. The FASEB Journal, 37(1).
Casanova-Vallve, N., Constantin-Teodosiu, D., Filer, A., Hardy, R. S., Greenhaff, P. L., & Chapman, V. (2020). Skeletal muscle dysregulation in rheumatoid arthritis: Metabolic and molecular markers in a rodent model and patients. PloS one, 15(7), e0235702.
Alvarez, P., Augustín, J. J., Tamayo, E., Iglesias, M., Acinas, O., Mendiguren, M. A., ... & Merino, R. (2020). Therapeutic effects of anti-Bone Morphogenetic Protein and Activin Membrane-Bound Inhibitor treatment in psoriasis and arthritis. Arthritis & Rheumatology.
Poolman, T. M., Gibbs, J., Walker, A. L., Dickson, S., Farrell, L., Hensman, J., ... & Rattray, M. (2019). Rheumatoid arthritis reprograms circadian output pathways. Arthritis Research & Therapy, 21(1), 47.
Chuang, H. C., Chen, Y. M., Chen, M. H., Hung, W. T., Yang, H. Y., Tseng, Y. H., & Tan, T. H. (2019). AhR–ROR-γt complex is a therapeutic target for MAP4K3/GLKhighIL-17A high subpopulation of systemic lupus erythematosus. The FASEB Journal, 33(10), 11469-11480.
Mariola Kurowska-Stolarska, Stefano Alivernini, Emma Garcia Melchor, et. al. MicroRNA-34a dependent regulation of AXL controls the activation of dendritic cells in inflammatory arthritis. Nature Communications (2017) 8, Article number 15877
77
Chris AH Hansel, Lindsay M MacLellan, Rachek S Oldham, et. al. The atypical chemokine receptor ACKR2 suppresses Th17 responses to protein autoantigens. Immunology and Cell Biology (2014), 1-10
Campo GM, Avenoso A, D'Ascola A, Nastasi G, et.al. Combined Treatment With Hyaluronan Inhibitor Pep-1 and a Selective Adenosine A2 Receptor Agonist Reduces Inflammation in Experimental Arthritis. Innate Immun. 2013;19(5):462-478
Eveline Trachsel, Frank Bootz, Michela Silacci, et. al. Antibody-mediated delivery of IL-10 inhibits the progression of established collagen-induced arthritis. Arthritis Research & Therapy (2007), 9:R9
Product Insert (PDF) - Informational use only. Please refer to insert included with product.
Data/Specifications:
- Format: Tan liquid with particles.
- Composition: 4 mg/mL M. Tuberculosis H37 RA (non-viable) in mineral oil.
- Application: For in-vivo/in-vitro studies. Typically used for the boost of an immune response.
- Storage: Keep tightly closed. Store at 2-8 °C. Do not freeze.
Related Products
Additional products you might interested in.
-
Collagen Type II, Bovine, Immunization Grade, Soluble, 2 mg/mLImmunization Grade Collagen type II (CII) protein, purified from fetal bovine articular cartilage, for the induction of arthritis in the Collagen-I...
-
Collagen Type II, Chicken, Lyophilized, 10 mgHighest quality (>99%) Collagen type II (CII) protein, purified from chicken sternum, for the induction of arthritis in the Collagen-Induced Art...
-
Collagen Type II, Chicken, Soluble, 2 mg/mLHighest quality (>99%) Collagen type II (CII) protein, purified from chicken sternum, for the induction of arthritis in the Collagen-Induced Art...
-
Complete Freund's Adjuvant, 10 mg/mL (5 mL)Complete Freund's Adjuvant (CFA or FCA) is 10 mg/ml M. Tuberculosis (non-viable) in mineral oil. Typically used to induce Adjuvant-Induced Arthriti...
-
Incomplete Freund's Adjuvant (IFA), 5 mLIncomplete Freund's Adjuvant (IFA or FIA) for booster injections. For in-vivo/in-vitro studies. Incomplete Freund's Adjuvant (IFA or FIA) is widely...
-
Human Collagen Type III, Lyophilized 0.1 mgHuman Collagen Type III protein purified from human placenta. Type III collagen is a fibrillar collagen, and it consists of only one collagen α ch...
-
Human Collagen Type I, Lyophilized 0.1 mgHuman Collagen Type I protein purified from human placenta. Type I collagen is the most abundant collagen and is found in connective tissues includ...
-
Human Collagen Type II, Lyophilized 0.1 mgHuman Collagen Type II protein purified from human cartilage. Collagen Type II is a fibrillar collagen, and the main component of cartilage. Type ...
-
Human Collagen Type IV, Lyophilized, 0.1mgHuman Collagen Type IV protein purified from human placenta. Collagen Type IV is a type of collagen found primarily in the skin within the basement...
-
Human Collagen Type V, Lyophilized, 0.1mgHuman Collagen Type V protein purified from human placenta. Collagen Type V is a fibrillar collagen. Collagen Type V is essential for the fibrilla...
-
Bovine Collagen Type VI, Lyophilized, 0.1mgBovine Collagen Type VI protein purified from bovine placenta. Collagen Type VI is the major collagenous component of microfibrils in elastic fibe...
-
Fibronectin, Human, 5mgFibronectin from human plasma. Fibronectin is a high-molecular-weight glycoprotein of the extracellular matrix that plays a crucial role in c...
-
Fibronectin 40 kDa Fragment Heparin Binding, Human, 0.5mgFibronectin heparin binding 40 kDa fragment. Chymotryptic digest of human plasma fibronectin. Heparin-binding 40 kDa fragment of human plasma...
-
Fibronectin 120 kDa Fragment Cell Attachment, Human, 0.5mgFibronectin heparin binding 120 kDa fragment. Chymotryptic digest of human plasma fibronectin. The Human Fibronectin 120 kDa cell attachment fra...
-
Alpha Fetoprotein, Human, 0.1mgAlpha Fetoprotein extracted from Human Blood Cord. Alpha-fetoprotein (AFP) is a glycoprotein produced mainly by the fetal liver, yolk sac, an...
-
ACC1, Monoclonal Antibody, 100ugThis antibody binds ACC1 to the citrullinated triple-helical collagen type II (CII) epitope (position 359-369), the C1 epitope. The ACC1 antibo...
-
Collagen Type II, Monoclonal Antibody (Clone M2139), 100ugThis antibody (clone 2139) recognizes the conformational J1 epitope on the triple-helical structure of the native Collagen Type II molecule. Th...
-
Collagen Type XI, Monoclonal Antibody, 100ugThis antibody (clone L10D9) binds to the triple-helical D3 epitope on collagen XI, which is shared with Collagen type II. The antibody binds to...
-
ACC4 (IgG1), Monoclonal Antibody, 100ugThis antibody is an anti-citrullinated protein antibody (ACPA) that, on Collagen alpha-1 (II) chain, binds specifically to citrullinated C1 epi...
-
ACC4 (IgG2b), Monoclonal Antibody, 100ugThis antibody is an anti-citrullinated protein antibody (ACPA) that on Collagen alpha-1 (II) chain binds specifically to citrullinated C1 epito...
-
ACPA, Monoclonal Antibody (Clone E4NG), 100ugThis antibody recognizes multiple citrullinated proteins/peptides, including CCP2, citrullinated collagen type 2 (COL2) peptides, citrullinated...
-
ACPA (Negative Control), Monoclonal Antibody (Clone E4NG-Mutant), 100ugThis antibody is a negative control for the E4NG antibody (product number 1061006). It is the mutated version of the E4NG antibody, with identi...
-
Cartilage Oligomeric Matrix Protein (COMP) , Monoclonal Antibody (Clone 15A11), 100ugThis antibody binds to the fourth EGF (Epithelial Growth Factor) -like domain of mouse COMP, comprising residues 232–252, called the P6 epitope...
-
Cartilage Oligomeric Matrix Protein (COMP), Monoclonal Antibody (Clone 16B5), 100ugThis antibody binds to the coiled-coil domain or pentamer COMP. It cross-reacts with mouse, rat and human. Cartilage Oligomeric Matrix Protein ...
-
Collagen Type II, Monoclonal Antibody (Clone CIIC1), 100ugThis antibody binds specifically to the C1 epitope on triple helica collagen type 2. It cross-reacts with mouse, rat, chicken, baboon and horse...
-
ArthritoMab™ Antibody Cocktail for Balb/c, DBA/1, R10.RIII, 50 mgArthritoMab™ Arthritis Inducing Antibody Cocktail is a cocktail of 4 arthritogenic monoclonal antibodies to collagen II (CII) used for inducing art...
-
ArthritoMab™ Antibody Cocktail for C57BL/6, TG, 50 mgArthritoMab™ Antibody Cocktail is a reformulated cocktail of 4 monoclonal antibodies for the induction of arthritis as an alternative to the widely...
-
Lipopolysaccharide (LPS), 5.0 mgHighly purified LPS for in vivo and in vitro use. Lipopolysaccharides (LPS), also known as lipoglyans and endotoxins, are large molecules consis...
-
Collagen Type II, Bovine, Immunization Grade, Lyophilized, 10 mgImmunization Grade Collagen type II (CII) protein, purified from fetal bovine articular cartilage, for the induction of arthritis in the Collagen-I...
-
Collagen Type II, Bovine, Immunization Grade, Soluble, 2 mg/mLImmunization Grade Collagen type II (CII) protein, purified from fetal bovine articular cartilage, for the induction of arthritis in the Collagen-I...
-
Collagen Type II, Chicken, Lyophilized, 10 mgHighest quality (>99%) Collagen type II (CII) protein, purified from chicken sternum, for the induction of arthritis in the Collagen-Induced Art...
-
Collagen Type II, Chicken, Soluble, 2 mg/mLHighest quality (>99%) Collagen type II (CII) protein, purified from chicken sternum, for the induction of arthritis in the Collagen-Induced Art...
-
Complete Freund's Adjuvant, 10 mg/mL (5 mL)Complete Freund's Adjuvant (CFA or FCA) is 10 mg/ml M. Tuberculosis (non-viable) in mineral oil. Typically used to induce Adjuvant-Induced Arthriti...
-
Incomplete Freund's Adjuvant (IFA), 5 mLIncomplete Freund's Adjuvant (IFA or FIA) for booster injections. For in-vivo/in-vitro studies. Incomplete Freund's Adjuvant (IFA or FIA) is widely...
-
Human Collagen Type III, Lyophilized 0.1 mgHuman Collagen Type III protein purified from human placenta. Type III collagen is a fibrillar collagen, and it consists of only one collagen α ch...
-
Human Collagen Type I, Lyophilized 0.1 mgHuman Collagen Type I protein purified from human placenta. Type I collagen is the most abundant collagen and is found in connective tissues includ...
-
Human Collagen Type II, Lyophilized 0.1 mgHuman Collagen Type II protein purified from human cartilage. Collagen Type II is a fibrillar collagen, and the main component of cartilage. Type ...
-
Human Collagen Type IV, Lyophilized, 0.1mgHuman Collagen Type IV protein purified from human placenta. Collagen Type IV is a type of collagen found primarily in the skin within the basement...
-
Human Collagen Type V, Lyophilized, 0.1mgHuman Collagen Type V protein purified from human placenta. Collagen Type V is a fibrillar collagen. Collagen Type V is essential for the fibrilla...
-
Bovine Collagen Type VI, Lyophilized, 0.1mgBovine Collagen Type VI protein purified from bovine placenta. Collagen Type VI is the major collagenous component of microfibrils in elastic fibe...
-
Fibronectin, Human, 5mgFibronectin from human plasma. Fibronectin is a high-molecular-weight glycoprotein of the extracellular matrix that plays a crucial role in c...
-
Fibronectin 40 kDa Fragment Heparin Binding, Human, 0.5mgFibronectin heparin binding 40 kDa fragment. Chymotryptic digest of human plasma fibronectin. Heparin-binding 40 kDa fragment of human plasma...
-
Fibronectin 120 kDa Fragment Cell Attachment, Human, 0.5mgFibronectin heparin binding 120 kDa fragment. Chymotryptic digest of human plasma fibronectin. The Human Fibronectin 120 kDa cell attachment fra...
-
Alpha Fetoprotein, Human, 0.1mgAlpha Fetoprotein extracted from Human Blood Cord. Alpha-fetoprotein (AFP) is a glycoprotein produced mainly by the fetal liver, yolk sac, an...
-
ACC1, Monoclonal Antibody, 100ugThis antibody binds ACC1 to the citrullinated triple-helical collagen type II (CII) epitope (position 359-369), the C1 epitope. The ACC1 antibo...
-
Collagen Type II, Monoclonal Antibody (Clone M2139), 100ugThis antibody (clone 2139) recognizes the conformational J1 epitope on the triple-helical structure of the native Collagen Type II molecule. Th...
-
Collagen Type XI, Monoclonal Antibody, 100ugThis antibody (clone L10D9) binds to the triple-helical D3 epitope on collagen XI, which is shared with Collagen type II. The antibody binds to...
-
ACC4 (IgG1), Monoclonal Antibody, 100ugThis antibody is an anti-citrullinated protein antibody (ACPA) that, on Collagen alpha-1 (II) chain, binds specifically to citrullinated C1 epi...
-
ACC4 (IgG2b), Monoclonal Antibody, 100ugThis antibody is an anti-citrullinated protein antibody (ACPA) that on Collagen alpha-1 (II) chain binds specifically to citrullinated C1 epito...
-
ACPA, Monoclonal Antibody (Clone E4NG), 100ugThis antibody recognizes multiple citrullinated proteins/peptides, including CCP2, citrullinated collagen type 2 (COL2) peptides, citrullinated...
-
ACPA (Negative Control), Monoclonal Antibody (Clone E4NG-Mutant), 100ugThis antibody is a negative control for the E4NG antibody (product number 1061006). It is the mutated version of the E4NG antibody, with identi...
-
Cartilage Oligomeric Matrix Protein (COMP) , Monoclonal Antibody (Clone 15A11), 100ugThis antibody binds to the fourth EGF (Epithelial Growth Factor) -like domain of mouse COMP, comprising residues 232–252, called the P6 epitope...
-
Cartilage Oligomeric Matrix Protein (COMP), Monoclonal Antibody (Clone 16B5), 100ugThis antibody binds to the coiled-coil domain or pentamer COMP. It cross-reacts with mouse, rat and human. Cartilage Oligomeric Matrix Protein ...
-
Collagen Type II, Monoclonal Antibody (Clone CIIC1), 100ugThis antibody binds specifically to the C1 epitope on triple helica collagen type 2. It cross-reacts with mouse, rat, chicken, baboon and horse...
-
ArthritoMab™ Antibody Cocktail for Balb/c, DBA/1, R10.RIII, 50 mgArthritoMab™ Arthritis Inducing Antibody Cocktail is a cocktail of 4 arthritogenic monoclonal antibodies to collagen II (CII) used for inducing art...
-
ArthritoMab™ Antibody Cocktail for C57BL/6, TG, 50 mgArthritoMab™ Antibody Cocktail is a reformulated cocktail of 4 monoclonal antibodies for the induction of arthritis as an alternative to the widely...
-
Lipopolysaccharide (LPS), 5.0 mgHighly purified LPS for in vivo and in vitro use. Lipopolysaccharides (LPS), also known as lipoglyans and endotoxins, are large molecules consis...
-
Collagen Type II, Bovine, Immunization Grade, Lyophilized, 10 mgImmunization Grade Collagen type II (CII) protein, purified from fetal bovine articular cartilage, for the induction of arthritis in the Collagen-I...
-
Collagen Type II, Bovine, Immunization Grade, Soluble, 2 mg/mLImmunization Grade Collagen type II (CII) protein, purified from fetal bovine articular cartilage, for the induction of arthritis in the Collagen-I...