CD80 (CTLA-4 / B7-1) Recombinant Protein, Human, 5μg

The human CD80 (CTLA-4 Counter-Receptor B7-1) is a recombinant protein consisting of a single glycosylated polypeptide chain with 216 amino acids (35-242aa). CD80 (B7-1) and CD86 (B7-2) are molecules upregulated on...

Cell Signaling Pathways

7059002

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For research use only. Not for use in diagnostic procedures.

The human CD80 (CTLA-4 Counter-Receptor B7-1) is a recombinant protein consisting of a single glycosylated polypeptide chain with 216 amino acids (35-242aa).

CD80 (B7-1) and CD86 (B7-2) are molecules upregulated on Antigen Presenting Cells (APCs) upon activation of Toll-Like Receptor (TLR) pathways, playing a crucial role in T cell activation by binding to the co-stimulatory molecule CD28. CTLA-4 (CD152) is expressed on activated T cells and binds to CD80 and CD86 with higher affinity than CD28, leading to the suppression of T cell activation. Blocking CTLA-4 signaling prolongs T cell activation and enhances anti-tumor responses. CTLA-4 was the first immune checkpoint targeted for cancer treatment.

 

Abbreviations: 

B-Lymphocyte Activation Antigen B7, CD80 Antigen (CD28 Antigen Ligand 1, B7-1 Antigen), CTLA-4 Counter-Receptor B7.1, Activation B7-1 Antigen, CD28LG1, CD28LG, CD80 Molecule, T-Lymphocyte Activation Antigen CD80, Costimulatory Factor CD80, CD80 Antigen, B7, Costimulatory Molecule Variant IgV-CD80, LAB7, BB1, B7.1.

Product Insert (PDF) - Informational use only. Please refer to insert included with product.

Data/Specifications:

  • Presentation: This protein is supplied in PBS (pH 7.4) and 10% glycerol.
  • Volume: 5μg / vial
  • Concentration: 0.5 mg/mL (Refer to the vial label for the concentration.)
  • Form: Soluble
  • Host: SF9
  • Molecular Weight: 24.9kDa
  • SDS PAGE Size: Appears at approximately 28-40kDa.
  • Purity: > 95%, as determined by SDS-PAGE
  • Storage: Stable at 4°C for one month or stored in the dark at -20°C long-term.