GITR (CD357, AITR) Recombinant Protein, Human, 10ug

The human Glucocorticoid-induced TNFR-related protein (GITR, CD357, AITR) is a recombinant protein consisting of a single glycosylated polypeptide chain with 145 amino acids (26-162aa). Glucocorticoid-induced TNFR-related protein (GITR), also known as...

Cell Signaling Pathways

7059015

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For research use only. Not for use in diagnostic procedures.

The human Glucocorticoid-induced TNFR-related protein (GITR, CD357, AITR) is a recombinant protein consisting of a single glycosylated polypeptide chain with 145 amino acids (26-162aa).

Glucocorticoid-induced TNFR-related protein (GITR), also known as TNFRSF18, GITR, and CD357, AITR (Activation-Inducible TNFR family member is a member of the TNF receptor superfamily. It significantly stimulates both acquired and innate immunity by promoting T effector function and inhibiting regulatory T cell (Treg) suppression. GITR is broadly expressed on various immune cells, particularly Tregs, natural killer (NK) cells, antigen-presenting cells (APCs), and tumor cells. Upon T cell activation, GITR expression is upregulated on Tregs and CD4+ and CD8+ effector T cells, making it an attractive target for cancer immunotherapy due to its potential to enhance immune responses against tumors.

Abbreviations:

GITR, CD357, GITR-D, TNFRSF18, Glucocorticoid-induced TNFR-related protein, AITR, Tumor necrosis factor receptor superfamily member 18, CD357, Activation-inducible TNFR family receptor, UNQ319/PRO364.

Product Insert (PDF) - Informational use only. Please refer to insert included with product.

Data/Specifications:

  • Presentation: This protein is supplied in PBS (pH 7.4) and 10% glycerol.
  • Volume: 10μg / vial
  • Concentration: 0.5 mg/mL (Refer to the vial label for the concentration.)
  • Form: Soluble
  • Host: SF9
  • Molecular Weight: 15.6kDa
  • Purity: > 98%, as determined by SDS-PAGE
  • Storage: Stable at 4°C for one month or stored in the dark at -20°C long-term.

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