PD-L2 (CD273) Recombinant Protein, Human, 20μg

The human Programmed cell death 1 ligand 2 (PD-L2) / CD273 is a recombinant protein consists of a single non-glycosylated polypeptide chain with 204 amino acids (20-200aa). Programmed cell death-1 (PD-1)...

Cell Signaling Pathways

7059008

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For research use only. Not for use in diagnostic procedures.

The human Programmed cell death 1 ligand 2 (PD-L2) / CD273 is a recombinant protein consists of a single non-glycosylated polypeptide chain with 204 amino acids (20-200aa).

Programmed cell death-1 (PD-1) is a key immunosuppressive molecule with two known ligands, PD-L1 and PD-L2. PD-L2 (also known as B7-DC or CD273), encoded by the PDCD1LG2 gene, plays a role in the negative regulation of the adaptive immune response as an immune checkpoint receptor ligand. Both PD-L1 and PD-L2 interact with PD-1 to modulate immune responses, making them significant targets in immunotherapy studies aimed at enhancing anti-tumor activity.

 

Abbreviations:

bA574F11.2, Butyrophilin B7-DC, PDCD1LG2, Btdc, PDCD1 ligand 2, PD-L2, Programmed death ligand 2, PDL2, PD-1 ligand 2, B7-DC, CD273, CD273, PDCD1L2, PD-L2.

Product Insert (PDF) - Informational use only. Please refer to insert included with product.

Data/Specifications:

  • Presentation: This protein is supplied in 20mM Tris-HCl buffer (pH 8.0), 0.4M Urea, and 10% glycerol.
  • Volume: 20μg / vial
  • Concentration: 1.0 mg/mL (Refer to the vial label for the concentration.)
  • Form: Soluble
  • Host: E. coli
  • Molecular Weight: 22.8kDa
  • Purity: > 95%, as determined by SDS-PAGE
  • Storage: Stable at 4°C for one month or stored in the dark at -20°C long-term.