4-1BB Receptor (CD137) Recombinant Protein, Human, 20μg

The 4-1BBR (TNFRSF9) is a receptor human recombinant protein consists of a single non-glycosylated polypeptide chain with 167 amino acids. 4-1BB (CD137), a member of the tumor necrosis factor receptor superfamily,...

Cell Signaling Pathways

7059013

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For research use only. Not for use in diagnostic procedures.

The 4-1BBR (TNFRSF9) is a receptor human recombinant protein consists of a single non-glycosylated polypeptide chain with 167 amino acids.

4-1BB (CD137), a member of the tumor necrosis factor receptor superfamily, is an inducible co-stimulatory receptor expressed on activated T cells and natural killer (NK) cells. First identified in 1989, 4-1BB triggers a signaling cascade upon ligation, leading to upregulation of antiapoptotic molecules, cytokine secretion, and enhanced effector functions. It is expressed on various cell types, including T cells, NK cells, dendritic cells (DCs), B cells, monocytes, and neutrophils. Interaction between 4-1BB and its ligand, 4-1BBL, positively regulates T-cell immunity, and several antibodies targeting 4-1BB have been shown to replicate this agonism, providing co- stimulatory signaling to T cells in vitro.

 

Abbreviations:

4-1BB, antigen 4-1BB homolog, CDw137, ILA, Tumor necrosis factor receptor superfamily member 9, T-cell antigen ILA, TNFRSF9, 4-1BB ligand receptor T-cell, 4-1BBR, CD137 antigen, MGC2172.

Product Insert (PDF) - Informational use only. Please refer to insert included with product.

Data/Specifications:

  • Volume: 20μg / vial
  • Form: Lyophilized
  • Host: E. coli
  • Molecular Weight: 17.7kDa
  • Purity: > 98%, as determined by SDS-PAGE
  • Storage: Stable at 4°C for one month or stored in the dark at -20°C long-term.