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Myelin Proteolipid Protein (PLP 139-151)

Catalog Number: 
301008
Qty/Size: 
15 mg

PLP 139-151 from MD Bioproducts

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Purified myelin proteolipid protein (PLP) for PLP-induced EAE models.

Overview

Overview: 

Multiple Sclerosis (MS) is a demyelinating disease of the central nervous system (CNS). The main characteristics of the disease are focal areas of demyelination and inflammation, however the pathogenesis is unclear.

 

Although no animal model thus far establishes all facets of human MS, Experimental Autoimmune Encephalomyelitis (EAE) represents the model most studied for the disease. Initially brain homogenates were used as antigens for immunization. Today, myelin related proteins or peptides are used in the disease.

Literature/Support

Literature/Support: 

Myelin Proteolipid Protein Insert (PDF)

References/Citations:

How Proteolipid protein (PLP) was used:
The novel small molecule drug Rabeximod is effective in reducing disease severity of mouse models of autoimmune disorders
M Hultqvist, K S Nandakumar, U Björklund, and R Holmdahl Ann Rheum Dis, Jan 2009; 68: 130 - 135.
Proteolipid protein (PLP) was used to induce EAE in SJL mice by subcutaneous injection. On day 0, 125 ug PLP/300 ug CFA per animal was used for induction and a supplemental immunostimulation with 20 ug/kg pertussis toxin was performed on day 0 and after 48 hrs.