The human GDNF recombinant protein consists of a single non-glycosylated polypeptide chain two 135 amino acids.

Glial cell line-derived neurotrophic factor (GDNF) is a potent protein that plays a crucial role in neural stem cell research due to its ability to promote neurons' survival, growth, and differentiation. GDNF is particularly effective in supporting the maintenance and proliferation of neural stem cells and enhancing their differentiation into dopaminergic neurons, which are essential for motor control and are often affected in neurodegenerative diseases like Parkinson's. Additionally, GDNF has neuroprotective properties that help preserve existing neurons and stimulate the regeneration of damaged neural tissues. Understanding and leveraging the effects of GDNF is vital for developing advanced therapeutic strategies to treat various neurological disorders and injuries.

Synonyms:

GDNF, HFB1-GDNF, ATF1, ATF2