BEND-6 Recombinant Protein (Human), 20ug

The human BEND-6 recombinant protein consists of a single, non-glycosylated polypeptide chain containing 302 amino acids (1-279 aa). BEN domain-containing protein 6 (BEND6) is a neural BEN-solo factor that functions similarly...

Cell Signaling Pathways

7059030

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For research use only. Not for use in diagnostic procedures.

The human BEND-6 recombinant protein consists of a single, non-glycosylated polypeptide chain containing 302 amino acids (1-279 aa).

BEN domain-containing protein 6 (BEND6) is a neural BEN-solo factor that functions similarly to the Drosophila co-repressor Insensitive. BEND6 binds to the mammalian CSL protein CBF1 and antagonizes Notch-dependent target activation. Its interaction with Notch- and CBF1-regulated enhancers is enhanced by CBF1 and inhibited by activated Notch. In utero electroporation experiments have shown that overexpression of BEND6 hinders Notch-mediated self-renewal of neocortical neural stem cells, thereby promoting neurogenesis.

 

Synonyms:

C6orf65, Chromosome 6 Open Reading Frame 65, BEN Domain Containing 6, bA203B9.1, BEN Domain-Containing Protein 6, BEND6

Product Insert (PDF) - Informational use only. Please refer to insert included with product.

Data/Specifications:

  • Presentation: This protein is supplied in 20mM Tris-HCl buffer (pH 8.0), 10% glycerol and 0.1M NaCl.
  • Volume: 20μg / vial
  • Form: Soluble
  • Host: E.coli
  • Molecular Weight: 33.6kDa
  • Purity: > 95%, as determined by SDS-PAGE


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