CNTF Recombinant Protein (Human), 20ug
The human CNTF recombinant protein consists of a single, non-glycosylated, polypeptide chain containing 199 amino acids. Ciliary neurotrophic factor (CNTF) is a neurotrophic factor in the four-helix bundle cytokine family, related...
Cell Signaling Pathways
7059029
The human CNTF recombinant protein consists of a single, non-glycosylated, polypeptide chain containing 199 amino acids.
Ciliary neurotrophic factor (CNTF) is a neurotrophic factor in the four-helix bundle cytokine family, related to interleukin-6 (IL-6), interleukin-11 (IL-11), leukemia inhibitory factor (LIF), and oncostatin M (OSM). It binds to the CNFTRα receptor, forming a heterodimer with the IL-6 receptor gp130 and LIF receptor (LIFR)-β, activating JAK/STAT, ERK, and PI3K signaling pathways. CNTF is crucial for neurogenesis and neural stem cell differentiation and has potential therapeutic applications for neurological disorders. It protects rod photoreceptors from light-induced damage, offers therapeutic benefits for retinal degenerative diseases, and protects oligodendrocytes from apoptosis. Additionally, CNTF is used to differentiate human pluripotent stem cell-derived neural progenitor cells into astrocytes.
Synonyms:
Ciliary Neurotrophic Factor, CNTF, HCNTF
Product Insert (PDF) - Informational use only. Please refer to insert included with product.
Data/Specifications:
- Volume: 20μg / vial
- Form: Lyophilized
- Host: E.coli
- Molecular Weight: 22.75kDa
- Purity: > 98%, as determined by SDS-PAGE