Aggrecan Antibody, C-terminal neoepitope NITEGE, 100 ug
Aggrecan monoclonal antibody to C-terminal neoepitope NITEGE (mouse, clone BC-13). This aggrecan degradation product usually remains within the tissue still complexed to hyaluronan and link protein. Its release from the cartilage...
Antibodies
1042003
Aggrecan monoclonal antibody to C-terminal neoepitope NITEGE (mouse, clone BC-13). This aggrecan degradation product usually remains within the tissue still complexed to hyaluronan and link protein. Its release from the cartilage usually signals that there has been extensive catabolism of aggrecan, which allows large complexes containing this metabolite to be released from the tissue.
Aggrecan is a member of a family of large, aggregating proteoglycans (also including versican, brevican and neurocan) which is found in articular cartilage. Aggrecan is composed of three major domains: G1, G2, and G3.
Between the G1 and G2 domains there is an interglobulin region (IGD). The IGD region is the major site of cleavage by specific proteases like metalloproteinases (MMPs) and aggrecanase. Aggrecan cleavage has been associated with a number of degenerative diseases including rheumatoid arthritis and osteoarthritis. There is evidence that this family of proteoglycans modulates cell adhesion, migration, and axonal outgrowth in the CNS.
References/Citations:
Kang, D., Lee, J., Jung, J., Carlson, B. A., Chang, M. J., Chang, C. B., ... & Kim, J. H. (2022). Selenophosphate synthetase 1 deficiency exacerbates osteoarthritis by dysregulating redox homeostasis. Nature Communications, 13(1), 1-14.
Collins, A.T., Hu, G., Newman, H. et al. Obesity alters the collagen organization and mechanical properties of murine cartilage. Sci Rep 11, 1626 (2021).
Ashinsky, B. G., Gullbrand, S. E., Bonnevie, E. D., Mandalapu, S. A., Wang, C., Elliott, D. M., ... & Smith, H. E. (2019). Multiscale and multimodal structure–function analysis of intervertebral disc degeneration in a rabbit model. Osteoarthritis and Cartilage, 27(12), 1860-1869.
Product Insert (PDF) - Informational use only. Please refer to insert included with product.
Specifications:
- Immunogen: NITEGE synthetic peptide conjugate.
- Clone: BC-13
- Host: Mouse
- Myeloma: x63-Ag8.653
- Isotype: IgG1 Light
- Chain type: kappa
- Specificity: Recognizes the aggrecanase (ADAMTS-1, -4 & -5)-generated C-terminal neoepitope ...TEGE after cleavage between amino acids ..EGE373 and 374ARG.. within the interglobular domain of aggrecanase-catabolised aggrecan (Human aggrecan sequence enumeration).
- Cross-reactivity: Human, Cow, Dog, Horse, Pig.
- Purity: Affinity purified on protein G
- Form: Liquid, 1 mL/vial Concentration: 0.1 mg/mL
Related Products
Additional products you might interested in.
-
Complete Freund's Adjuvant, 4 mg/mL (5 mL)Complete Freund's Adjuvant (CFA or FCA) is 4 mg/ml M. Tuberculosis (non-viable) in mineral oil. For in-vivo/in-vitro studies. Typically used for th...
-
T1/ST2 (IL-33 R) Mouse, Monoclonal Antibody, PE Conjugated, 0.1 mLMouse T1/ST2 (IL-33 R) PE conjugated monoclonal antibody (Clone DJ8, Host / Isotype Subclass: Rat IgG1, light chain not isotyped) for the identific...
-
T1/ST2 (IL-33R) Mouse, Monoclonal Antibody, FITC, 0.5 mLMouse T1/ST2 (IL-33 R) FITC conjugated monoclonal antibody (Clone: DJ8, Host / Isotype Subclass: Rat IgG1, light chain not isotyped) for the identi...
-
Lipopolysaccharide (LPS), 5.0 mgHighly purified LPS for in vivo and in vitro use. Lipopolysaccharides (LPS), also known as lipoglyans and endotoxins, are large molecules consis...
-
T1/ST2 (IL-33 R) Mouse, Monoclonal Antibody, Biotinylated, 0.5 mLMouse T1/ST2 (IL-33 R) biotinylated monoclonal antibody (Clone: DJ8, Host / Isotype Subclass: Rat IgG1, light chain not isotyped) for the identific...
-
Collagen Type II, Chicken, Soluble, 2 mg/mLHighest quality (>99%) Collagen type II (CII) protein, purified from chicken sternum, for the induction of arthritis in the Collagen-Induced Art...
-
NeuroFreezeFor the preservation of primary neurons from rat and mouse hippocampi and cortices. 10 mL or 30 mL The NeuroFreeze kit can be used to freeze prim...
-
Goat anti-Mouse IgD, Antiserum, 1 mLImmunoglobulin D activator for B-cells. Preservative-free for in vivo application. Immunoglobulin D (IgD) is an antibody isotype that is found prim...
-
Collagen Type II, Chicken, Lyophilized, 10 mgHighest quality (>99%) Collagen type II (CII) protein, purified from chicken sternum, for the induction of arthritis in the Collagen-Induced Art...
-
Collagen Type II, Bovine, Immunization Grade, Lyophilized, 10 mgImmunization Grade Collagen type II (CII) protein, purified from fetal bovine articular cartilage, for the induction of arthritis in the Collagen-I...
-
ArthritoMab™ Antibody Cocktail for Balb/c, DBA/1, R10.RIII, 50 mgArthritoMab™ Arthritis Inducing Antibody Cocktail is a cocktail of 4 arthritogenic monoclonal antibodies to collagen II (CII) used for inducing art...
-
ST2L Human, Monoclonal Antibody, Biotinylated, 200 uLHuman ST2L biotinylated monoclonal antibody (Clone: B4E6, Host / Isotype Subclass: Mouse IgG1), for the identification and purification of human t...
-
Myelin Oligodendrocyte Glycoprotein (MOG 35-55), 25 mgPurified myelin oligodendrocyte glycoprotein (MOG) for MOG-induced EAE models in mouse and rat. Multiple Sclerosis (MS) is a demyelinating disease...
-
Lubricin Antibody, Native Bovine, 100 ugLubricin (PRG4) monoclonal antibody (mouse, clone 3A4) to detect the native form of bovine lubricin. Does not recognize reduced or denatured lubric...
-
Keratan Sulfate Antibody, 100 ugKeratan sulfate (KS) monoclonal antibody (mouse, clone 5D4) used to detect KS type I epitopes and KS type II epitopes. Liquid. Store at -20° C. K...
-
Collagen Type I and III, Porcine, 10 mgPurified type I & III native porcine collagen from pig’s tissue, 10 mg. Highest quality collagen for research use. Type I collagen is the mo...
-
Collagen Type I and III, Canine, 10 mgPurified type I & III canine collagen. Type I collagen is the most abundant collagen and is found in connective tissues including tendon, ligam...
-
Bovine Collagen Type VI, Lyophilized, 0.1mgBovine Collagen Type VI protein purified from human placenta. Collagen Type VI is the major collagenous component of microfibrils in elastic fiber...
-
Human Collagen Type V, Lyophilized, 0.1mgHuman Collagen Type V protein purified from human placenta. Collagen Type V is a fibrillar collagen. Collagen Type V is essential for the fibrilla...
-
Human Collagen Type IV, Lyophilized, 0.1mgHuman Collagen Type IV protein purified from human placenta. Collagen Type IV is a type of collagen found primarily in the skin within the basement...
-
Human Collagen Type III, Lyophilized 0.1 mgHuman Collagen Type III protein purified from human placenta. Type III collagen is a fibrillar collagen, and it consists of only one collagen α ch...
-
Human Collagen Type I, Lyophilized 0.1 mgHuman Collagen Type I protein purified from human placenta. Type I collagen is the most abundant collagen and is found in connective tissues includ...
-
Human Collagen Type II, Lyophilized 0.1 mgHuman Collagen Type II protein purified from human cartilage. Collagen Type II is a fibrillar collagen, and the main component of cartilage. Type ...
-
Complete Freund's Adjuvant, 10 mg/mL (5 mL)Complete Freund's Adjuvant (CFA or FCA) is 10 mg/ml M. Tuberculosis (non-viable) in mineral oil. Typically used to induce Adjuvant-Induced Arthriti...
-
MonELISA® Mouse IL-17aMonELISA® Mouse IL-17a is an assay using antibodies generated specifically to the entire murine IL-17a protein without any cross-reactivity to othe...
-
MonELISA® Canine IL-17aMonELISA® Canine IL-17a is an assay using antibodies generated specifically to the entire canine IL-17a protein without any cross-reactivity to oth...
-
ArthritoMab™ Antibody Cocktail for C57BL/6, TG, 50 mgArthritoMab™ Antibody Cocktail is a reformulated cocktail of 4 monoclonal antibodies for the induction of arthritis as an alternative to the widely...
-
MonELISA® Uromodulin Glycoprotein (Tamm-Horsfall Glycoprotein, THP) ELISAThe MonELISA® Uromodulin Glycoprotein ELISA kit is used for the quantitative determination of Uromodulin Glycoprotein (THP) in urine and serum samp...
-
T1/ST2 (IL-33 R) Mouse, Monoclonal Antibody, 0.5 mLMouse T1/ST2 (IL-33 R) monoclonal antibody (Clone: DJ8, Host / Isotype Subclass: Rat IgG1, light chain not isotyped) for the identification and pur...
-
T1/ST2 (IL-33 R) Monoclonal Antibody, azide-free, 0.5 mLMouse T1/ST2 (IL-33 R) monoclonal antibody (Clone DJ8, Host / Isotype Subclass: Rat IgG1, light chain not isotyped), azide-free, for the identific...
-
ST2L Human, Monoclonal Antibody, FITC, 200 uLHuman ST2L FITC conjugated monoclonal antibody (Clone: B4E6, Host / Isotype Subclass: Mouse IgG1), for the identification and purification of human...
-
ST2L Human, Monoclonal Antibody, 200 uLHuman ST2L monoclonal antibody (Clone: B4E6, Host / Isotype Subclass: Mouse IgG1), for the identification and purification of human type 2 (Th2) ly...
-
Rat IgG1 Isotype Control, R-PE Conjugated Antibody, 0.1 mgIsotype controls are most commonly used in flow cytometry and immunohistochemistry experiments as negative controls that measure the level of non-s...
-
Rat IgG1 Isotype Control, Purified Antibody, 0.5 mgIsotype controls are most commonly used in flow cytometry and immunohistochemistry experiments as negative controls that measure the level of non-s...
-
Rat IgG1 Isotype Control, Low endotoxin, Azide-free, 0.5 mgIsotype controls are most commonly used in flow cytometry and immunohistochemistry experiments as negative controls that measure the level of non-s...
-
Rat IgG1 Isotype Control, FITC Conjugated Antibody, 0.5 mgIsotype controls are most commonly used in flow cytometry and immunohistochemistry experiments as negative controls that measure the level of non-s...
-
Rat IgG1 Isotype Control, Biotin Conjugated Antibody, 0.5 mgIsotype controls are most commonly used in flow cytometry and immunohistochemistry experiments as negative controls that measure the level of non-s...
-
Myelin Proteolipid Protein (PLP 139-151), 15 mgPurified myelin proteolipid protein (PLP) for PLP-induced EAE models in mouse and rat. Multiple Sclerosis (MS) is a demyelinating disease of the c...
-
MonELISA® Collagen Type II Anti-Mouse IgG2b ELISAThe MonELISA® Collagen Type II (CII) Antibody ELISA kit is used to measure IgG2b antibodies generated against mouse type II collagen used in the in...
-
Mouse IgG1 Isotype Control, Purified Antibody, 1 mgMouse IgG1 Isotype control, purified. This product supplied as 1.0 mg of purified immunoglobulin in 1.0 mL of borate buffered saline, pH 8.2. Iso...
-
Mouse IgG1 Isotype Control, low endotoxin, azide-free, 0.5 mgMouse IgG1 Isotype control, Low endotoxin, azide-free. The low endotoxin, azide-free antibody is supplied as 0.5 mg purified immunoglobulin in 1.0 ...
-
Mouse IgG1 Isotype Control, FITC-conjugated Antibody, 0.1 mgMouse IgG1 Isotype control, FITC-conjugated. The fluorescein (FITC) conjugate is supplied in 1.0 mL PBS/NaN3. Store at 2 – 8 °C Isotype controls ...
-
Mouse IgG1 Isotype Control, Biotin-conjugated Antibody, 0.5 mgMouse IgG1 Isotype control, Biotin Conjugated. The biotin conjugate is supplied as 0.5 mg in 1.0 mL of PBS/NaN3. Store at 2 – 8 °C. Isotype contr...
-
Lumican, Antibody, 100 ugLumican (LUM) monoclonal antibody (mouse, clone Lum-1) to detect a protein epitope in lumican. Liquid, 1 mL/vial. Concentration: 0.1 mg/mL Lumica...
-
Lubricin Antibody, Bovine, 100 ugLubricin (PRG4) monoclonal antibody (mouse, clone 6A1) to detect superficial zone protein (SZP) from bovine articular cartilage and a non conformat...
-
Keratocan Antibody, 100 ugKeratocan (KERA) monoclonal antibody (mouse, clone Ker-1) to detect keratocan. 1 mL/vial. Concentration is 0.1 mg/mL. Normal keratocan expressio...
-
Collagen Type V (Atelocollagen), Bovine, 1 mgPurified Bovine Collagen Type V from bovine placenta (atelocollagen).
-
Collagen Type IV Antibody, anti-Rat, 100 uLAffinity chromatography purified rabbit antibody to rat type IV collagen extracted, purified from rodent tumor tissues. Purified, freeze-dried (0.5...
-
Collagen Type IV Antibody, anti-Mouse, 100 uLCollagen Type IV polyclonal antibody (rabbit anti-mouse) purified from rabbits injected with type IV collagen that was extracted/purified from mous...