Mouse T1/ST2 (IL-33 R) monoclonal antibody (Clone DJ8, Host / Isotype Subclass: Rat IgG1, light chain not isotyped), azide-free,  for the identification and purification of murine T helper 2 (Th2) cells and all forms of murine mast cells.

T1/ST2 (also known as IL-1 R4 or IL-33Ra) is a transmembrane glycoprotein expressed on mast cells and Th2 cells. It is a selective marker for both murine and human Th2 lymphocytes and plays a role in regulating inflammatory responses. IL-33 is a recently identified member of the IL-1 family of cytokines and is involved in Th2 mediated immune responses. IL-33 mediates its biological effects via T1/ST2 binding. The roles of IL-33 and T1/ST2 (IL-33Ra) have been investigated in many immune responses such as allergy, asthma, rheumatoid arthritis and osteoarthritis.

References/Citations:

Yan, C., Kuang, W., Ma, G., Guo, F., Jin, L., Wan, H., ... & Wang, L. (2025). E3 ligase RNF128 restricts A. alternata-induced ILC2 activation and type 2 immune response in the murine lung. Scientific Reports, 15(1), 1193.

IL-33 induces IL-13-dependent cutaneous fibrosis.
Rankin A, et al. Journ. of Immunol., 2010; 184(3):1526-35

IL-33 Enhances Lipopolysaccharide-Induced Inflammatory Cytokine Production from Mouse Macrophages by Regulating Lipopolysaccharide Receptor Complex
Quentin Espinassous et al., J. Immunol., Jul 2009; 183: 1446 - 1455.

Interleukin-1 receptor-related protein ST2 suppresses the initial stage of bleomycin-induced lung injury N. Mato et al., Eur. Respir. J., Jun 2009; 33: 1415 - 1428.

IL-1 receptor accessory protein and ST2 comprise the IL-33 receptor complex. Chackerian A, et al. Journ. of Immunol., 2007; 179(4):2551-5.

IL-17 Promotes Immune Privilege of Corneal Allografts Khrishen Cunnusamy, Peter W. Chen, and Jerry Y. Niederkorn
J. Immunol., Oct 2010; 185: 4651 - 4658.

Predominance of Th2 response in human abdominal aortic aneurysm: Mistaken identity for IL-4-producing NK and NKT cells? Chan WL, et al. Cellular Immun (2005) 233:109-114Changes in systemic type 1 and type 2 immunity in normal pregnancy and pre-eclampsia may be mediated by natural killer cells Borzychowski, A.M. et al., Eur J Immunol (2005) 35:3054-3063.

Atherosclerotic Abdominal Aortic Aneurysm and the Interaction Between Autologous Human Plaque-Derived Vascular Smooth Muscle Cells, Type-1 NKT, and Helper T-Cells Chan, W.L. et al., Circ Res (2005) 96:675-683NKT cell subsets in infection and inflammation Chan WL, et al. Immun Lett (2003) 85:159-163

Regulation of ST2L expression on T helper (Th) type 2 cells Carter, R.W. et al., Eur. J. Immunol. (2001) 31:2979-2985Human IL-18 Receptor and ST@L Are Stable and Selective markers for the Respective Type 1 and Type 2 Circulating Lymphocytes Chan WL, et al. J Immunol. 2001 Aug 1; 167(3):1238-44.