T1/ST2 (IL-33 R) Monoclonal Antibody, azide-free, 0.5 mL
Mouse T1/ST2 (IL-33 R) monoclonal antibody (Clone DJ8, Host / Isotype Subclass: Rat IgG1, light chain not isotyped), azide-free, for the identification and purification of murine T helper 2 (Th2) cells...
Antibodies
101001N
Mouse T1/ST2 (IL-33 R) monoclonal antibody (Clone DJ8, Host / Isotype Subclass: Rat IgG1, light chain not isotyped), azide-free, for the identification and purification of murine T helper 2 (Th2) cells and all forms of murine mast cells.
T1/ST2 (also known as IL-1 R4 or IL-33Ra) is a transmembrane glycoprotein expressed on mast cells and Th2 cells. It is a selective marker for both murine and human Th2 lymphocytes and plays a role in regulating inflammatory responses. IL-33 is a recently identified member of the IL-1 family of cytokines and is involved in Th2 mediated immune responses. IL-33 mediates its biological effects via T1/ST2 binding. The roles of IL-33 and T1/ST2 (IL-33Ra) have been investigated in many immune responses such as allergy, asthma, rheumatoid arthritis and osteoarthritis.
References/Citations:
IL-33 induces IL-13-dependent cutaneous fibrosis.
Rankin A, et al. Journ. of Immunol., 2010; 184(3):1526-35
IL-33 Enhances Lipopolysaccharide-Induced Inflammatory Cytokine Production from Mouse Macrophages by Regulating Lipopolysaccharide Receptor Complex
Quentin Espinassous et al., J. Immunol., Jul 2009; 183: 1446 - 1455.
Interleukin-1 receptor-related protein ST2 suppresses the initial stage of bleomycin-induced lung injury N. Mato et al., Eur. Respir. J., Jun 2009; 33: 1415 - 1428.
IL-1 receptor accessory protein and ST2 comprise the IL-33 receptor complex. Chackerian A, et al. Journ. of Immunol., 2007; 179(4):2551-5.
IL-17 Promotes Immune Privilege of Corneal Allografts Khrishen Cunnusamy, Peter W. Chen, and Jerry Y. Niederkorn
J. Immunol., Oct 2010; 185: 4651 - 4658.
Predominance of Th2 response in human abdominal aortic aneurysm: Mistaken identity for IL-4-producing NK and NKT cells? Chan WL, et al. Cellular Immun (2005) 233:109-114Changes in systemic type 1 and type 2 immunity in normal pregnancy and pre-eclampsia may be mediated by natural killer cells Borzychowski, A.M. et al., Eur J Immunol (2005) 35:3054-3063.
Atherosclerotic Abdominal Aortic Aneurysm and the Interaction Between Autologous Human Plaque-Derived Vascular Smooth Muscle Cells, Type-1 NKT, and Helper T-Cells Chan, W.L. et al., Circ Res (2005) 96:675-683NKT cell subsets in infection and inflammation Chan WL, et al. Immun Lett (2003) 85:159-163
Regulation of ST2L expression on T helper (Th) type 2 cells Carter, R.W. et al., Eur. J. Immunol. (2001) 31:2979-2985Human IL-18 Receptor and ST@L Are Stable and Selective markers for the Respective Type 1 and Type 2 Circulating Lymphocytes Chan WL, et al. J Immunol. 2001 Aug 1; 167(3):1238-44.
Product Insert (PDF) - Informational use only. Please refer to insert included with product.
Data/Specifications:
- Rat anti-Mouse T1/ST2 purified mAb, azide-free
- Clone: DJ8
- Host / Isotype Subclass: Rat IgG1 (light chain not isotyped)
- Form: The antibody is supplied in PBS and purified over protein G-sepharose. The characteristics of each lot are tested by FACS analysis with bone marrow derived mast cells.
- Specificity: This clone recognizes the membrane anchored murine T1M protein on the surface of T helper 2 cells and mast cells. T1M appears on fetal blood derived mast cell progenitors before they express the Fce RI, on IL-3-dependent bone marrow derived mast cells and on mature peritoneal mast cells. The antibody detects T1S protein consisting only of the extracellular portion of the protein, which is secreted from growth factor and proinflammatory cytokine stimulated murine fibroblasts.
- Immunogen: Eukariotically expressed fusion protein of mouse T1 ectodomain and human immunoglobulin Fc domain.
Related Products
Additional products you might interested in.
-
Complete Freund's Adjuvant, 4 mg/mL (5 mL)Complete Freund's Adjuvant (CFA or FCA) is 4 mg/ml M. Tuberculosis (non-viable) in mineral oil. For in-vivo/in-vitro studies. Typically used for th...
-
T1/ST2 (IL-33 R) Mouse, Monoclonal Antibody, PE Conjugated, 0.1 mLMouse T1/ST2 (IL-33 R) PE conjugated monoclonal antibody (Clone DJ8, Host / Isotype Subclass: Rat IgG1, light chain not isotyped) for the identific...
-
T1/ST2 (IL-33R) Mouse, Monoclonal Antibody, FITC, 0.5 mLMouse T1/ST2 (IL-33 R) FITC conjugated monoclonal antibody (Clone: DJ8, Host / Isotype Subclass: Rat IgG1, light chain not isotyped) for the identi...
-
Lipopolysaccharide (LPS), 5.0 mgHighly purified LPS for in vivo and in vitro use. Lipopolysaccharides (LPS), also known as lipoglyans and endotoxins, are large molecules consis...
-
T1/ST2 (IL-33 R) Mouse, Monoclonal Antibody, Biotinylated, 0.5 mLMouse T1/ST2 (IL-33 R) biotinylated monoclonal antibody (Clone: DJ8, Host / Isotype Subclass: Rat IgG1, light chain not isotyped) for the identific...
-
Aggrecan Antibody, C-terminal neoepitope NITEGE, 100 ugAggrecan monoclonal antibody to C-terminal neoepitope NITEGE (mouse, clone BC-13). This aggrecan degradation product usually remains within the tis...
-
Collagen Type II, Chicken, Soluble, 2 mg/mLHighest quality (>99%) Collagen type II (CII) protein, purified from chicken sternum, for the induction of arthritis in the Collagen-Induced Art...
-
NeuroFreezeFor the preservation of primary neurons from rat and mouse hippocampi and cortices. 10 mL or 30 mL The NeuroFreeze kit can be used to freeze prim...
-
Goat anti-Mouse IgD, Antiserum, 1 mLImmunoglobulin D activator for B-cells. Preservative-free for in vivo application. Immunoglobulin D (IgD) is an antibody isotype that is found prim...
-
Collagen Type II, Chicken, Lyophilized, 10 mgHighest quality (>99%) Collagen type II (CII) protein, purified from chicken sternum, for the induction of arthritis in the Collagen-Induced Art...
-
Collagen Type II, Bovine, Immunization Grade, Lyophilized, 10 mgImmunization Grade Collagen type II (CII) protein, purified from fetal bovine articular cartilage, for the induction of arthritis in the Collagen-I...
-
ArthritoMab™ Antibody Cocktail for Balb/c, DBA/1, R10.RIII, 50 mgArthritoMab™ Arthritis Inducing Antibody Cocktail is a cocktail of 4 arthritogenic monoclonal antibodies to collagen II (CII) used for inducing art...
-
ST2L Human, Monoclonal Antibody, Biotinylated, 200 uLHuman ST2L biotinylated monoclonal antibody (Clone: B4E6, Host / Isotype Subclass: Mouse IgG1), for the identification and purification of human t...
-
Myelin Oligodendrocyte Glycoprotein (MOG 35-55), 25 mgPurified myelin oligodendrocyte glycoprotein (MOG) for MOG-induced EAE models in mouse and rat. Multiple Sclerosis (MS) is a demyelinating disease...
-
Lubricin Antibody, Native Bovine, 100 ugLubricin (PRG4) monoclonal antibody (mouse, clone 3A4) to detect the native form of bovine lubricin. Does not recognize reduced or denatured lubric...
-
Keratan Sulfate Antibody, 100 ugKeratan sulfate (KS) monoclonal antibody (mouse, clone 5D4) used to detect KS type I epitopes and KS type II epitopes. Liquid. Store at -20° C. K...
-
Collagen Type I and III, Porcine, 10 mgPurified type I & III native porcine collagen from pig’s tissue, 10 mg. Highest quality collagen for research use. Type I collagen is the mo...
-
Collagen Type I and III, Canine, 10 mgPurified type I & III canine collagen. Type I collagen is the most abundant collagen and is found in connective tissues including tendon, ligam...
-
Bovine Collagen Type VI, Lyophilized, 0.1mgBovine Collagen Type VI protein purified from human placenta. Collagen Type VI is the major collagenous component of microfibrils in elastic fiber...
-
Human Collagen Type V, Lyophilized, 0.1mgHuman Collagen Type V protein purified from human placenta. Collagen Type V is a fibrillar collagen. Collagen Type V is essential for the fibrilla...
-
Human Collagen Type IV, Lyophilized, 0.1mgHuman Collagen Type IV protein purified from human placenta. Collagen Type IV is a type of collagen found primarily in the skin within the basement...
-
Human Collagen Type III, Lyophilized 0.1 mgHuman Collagen Type III protein purified from human placenta. Type III collagen is a fibrillar collagen, and it consists of only one collagen α ch...
-
Human Collagen Type I, Lyophilized 0.1 mgHuman Collagen Type I protein purified from human placenta. Type I collagen is the most abundant collagen and is found in connective tissues includ...
-
Human Collagen Type II, Lyophilized 0.1 mgHuman Collagen Type II protein purified from human cartilage. Collagen Type II is a fibrillar collagen, and the main component of cartilage. Type ...
-
Complete Freund's Adjuvant, 10 mg/mL (5 mL)Complete Freund's Adjuvant (CFA or FCA) is 10 mg/ml M. Tuberculosis (non-viable) in mineral oil. Typically used to induce Adjuvant-Induced Arthriti...
-
MonELISA® Mouse IL-17aMonELISA® Mouse IL-17a is an assay using antibodies generated specifically to the entire murine IL-17a protein without any cross-reactivity to othe...
-
MonELISA® Canine IL-17aMonELISA® Canine IL-17a is an assay using antibodies generated specifically to the entire canine IL-17a protein without any cross-reactivity to oth...
-
ArthritoMab™ Antibody Cocktail for C57BL/6, TG, 50 mgArthritoMab™ Antibody Cocktail is a reformulated cocktail of 4 monoclonal antibodies for the induction of arthritis as an alternative to the widely...
-
MonELISA® Uromodulin Glycoprotein (Tamm-Horsfall Glycoprotein, THP) ELISAThe MonELISA® Uromodulin Glycoprotein ELISA kit is used for the quantitative determination of Uromodulin Glycoprotein (THP) in urine and serum samp...
-
T1/ST2 (IL-33 R) Mouse, Monoclonal Antibody, 0.5 mLMouse T1/ST2 (IL-33 R) monoclonal antibody (Clone: DJ8, Host / Isotype Subclass: Rat IgG1, light chain not isotyped) for the identification and pur...
-
ST2L Human, Monoclonal Antibody, FITC, 200 uLHuman ST2L FITC conjugated monoclonal antibody (Clone: B4E6, Host / Isotype Subclass: Mouse IgG1), for the identification and purification of human...
-
ST2L Human, Monoclonal Antibody, 200 uLHuman ST2L monoclonal antibody (Clone: B4E6, Host / Isotype Subclass: Mouse IgG1), for the identification and purification of human type 2 (Th2) ly...
-
Rat IgG1 Isotype Control, R-PE Conjugated Antibody, 0.1 mgIsotype controls are most commonly used in flow cytometry and immunohistochemistry experiments as negative controls that measure the level of non-s...
-
Rat IgG1 Isotype Control, Purified Antibody, 0.5 mgIsotype controls are most commonly used in flow cytometry and immunohistochemistry experiments as negative controls that measure the level of non-s...
-
Rat IgG1 Isotype Control, Low endotoxin, Azide-free, 0.5 mgIsotype controls are most commonly used in flow cytometry and immunohistochemistry experiments as negative controls that measure the level of non-s...
-
Rat IgG1 Isotype Control, FITC Conjugated Antibody, 0.5 mgIsotype controls are most commonly used in flow cytometry and immunohistochemistry experiments as negative controls that measure the level of non-s...
-
Rat IgG1 Isotype Control, Biotin Conjugated Antibody, 0.5 mgIsotype controls are most commonly used in flow cytometry and immunohistochemistry experiments as negative controls that measure the level of non-s...
-
Myelin Proteolipid Protein (PLP 139-151), 15 mgPurified myelin proteolipid protein (PLP) for PLP-induced EAE models in mouse and rat. Multiple Sclerosis (MS) is a demyelinating disease of the c...
-
MonELISA® Collagen Type II Anti-Mouse IgG2b ELISAThe MonELISA® Collagen Type II (CII) Antibody ELISA kit is used to measure IgG2b antibodies generated against mouse type II collagen used in the in...
-
Mouse IgG1 Isotype Control, Purified Antibody, 1 mgMouse IgG1 Isotype control, purified. This product supplied as 1.0 mg of purified immunoglobulin in 1.0 mL of borate buffered saline, pH 8.2. Iso...
-
Mouse IgG1 Isotype Control, low endotoxin, azide-free, 0.5 mgMouse IgG1 Isotype control, Low endotoxin, azide-free. The low endotoxin, azide-free antibody is supplied as 0.5 mg purified immunoglobulin in 1.0 ...
-
Mouse IgG1 Isotype Control, FITC-conjugated Antibody, 0.1 mgMouse IgG1 Isotype control, FITC-conjugated. The fluorescein (FITC) conjugate is supplied in 1.0 mL PBS/NaN3. Store at 2 – 8 °C Isotype controls ...
-
Mouse IgG1 Isotype Control, Biotin-conjugated Antibody, 0.5 mgMouse IgG1 Isotype control, Biotin Conjugated. The biotin conjugate is supplied as 0.5 mg in 1.0 mL of PBS/NaN3. Store at 2 – 8 °C. Isotype contr...
-
Lumican, Antibody, 100 ugLumican (LUM) monoclonal antibody (mouse, clone Lum-1) to detect a protein epitope in lumican. Liquid, 1 mL/vial. Concentration: 0.1 mg/mL Lumica...
-
Lubricin Antibody, Bovine, 100 ugLubricin (PRG4) monoclonal antibody (mouse, clone 6A1) to detect superficial zone protein (SZP) from bovine articular cartilage and a non conformat...
-
Keratocan Antibody, 100 ugKeratocan (KERA) monoclonal antibody (mouse, clone Ker-1) to detect keratocan. 1 mL/vial. Concentration is 0.1 mg/mL. Normal keratocan expressio...
-
Collagen Type V (Atelocollagen), Bovine, 1 mgPurified Bovine Collagen Type V from bovine placenta (atelocollagen).
-
Collagen Type IV Antibody, anti-Rat, 100 uLAffinity chromatography purified rabbit antibody to rat type IV collagen extracted, purified from rodent tumor tissues. Purified, freeze-dried (0.5...
-
Collagen Type IV Antibody, anti-Mouse, 100 uLCollagen Type IV polyclonal antibody (rabbit anti-mouse) purified from rabbits injected with type IV collagen that was extracted/purified from mous...